Perioperative changes in plasma fibrinogen concentration. Measurements were performed on admission to the emergency room (ER), on arrival at the intensive care unit (ICU), 24 hours after admission to the ER, on the third and the seventh postoperative days. The hatched area shows the normal physiological range of plasma fibrinogen concentration. The boxes represent the interquartile range, the lines represent the mean, and the whiskers extend to 95% confidence interval for the mean. The circles represent outside values, larger that the upper quartile plus 1.5 times the interquartile range, and the squares represent far out values, larger that the upper quartile plus three times the interquartile range.