Table 4 Differences between patients with optimal (>64 μg/ml) and inadequate (<64 μg/ml) peak amikacin concentrations
From: Revisiting the loading dose of amikacin for patients with severe sepsis and septic shock
Peak >64 (n = 52) | Peak <64 (n = 22) | |
|---|---|---|
Male | 32 (62) | 18 (81) |
Nosocomial infections | 37 (71) | 15 (68) |
Medical admission | 37 (71) | 13 (59) |
Positive blood cultures | 18 (35) | 11 (50) |
Shock/vasopressors | 40 (76) | 16 (72) |
Mechanical ventilation | 37 (71) | 19 (86) |
Age (years) | 62 ± 14 | 64 ± 13 |
APACHE II score | 20 (16-25) | 23 (16-28) |
SOFA score | 8 (5-10) | 9 (5-11) |
Highest lactate (mmol/L) | 3.1 (1.5-4.8) | 2.8 (1.3-5.2) |
Creatinine (mg/ml) | 1.6 ± 1.1 | 1.7 ± 1.3 |
Albumin (g/dl) | 2.4 ± 0.8 | 2.4 ± 0.8 |
Fluid balance (ml/24 h) | 2,589 ± 2,153 | 2,793 ± 2,085 |