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Table 4 Differences between patients with optimal (>64 μg/ml) and inadequate (<64 μg/ml) peak amikacin concentrations

From: Revisiting the loading dose of amikacin for patients with severe sepsis and septic shock

  Peak >64
(n = 52)
Peak <64
(n = 22)
Male 32 (62) 18 (81)
Nosocomial infections 37 (71) 15 (68)
Medical admission 37 (71) 13 (59)
Positive blood cultures 18 (35) 11 (50)
Shock/vasopressors 40 (76) 16 (72)
Mechanical ventilation 37 (71) 19 (86)
Age (years) 62 ± 14 64 ± 13
APACHE II score 20 (16-25) 23 (16-28)
SOFA score 8 (5-10) 9 (5-11)
Highest lactate (mmol/L) 3.1 (1.5-4.8) 2.8 (1.3-5.2)
Creatinine (mg/ml) 1.6 ± 1.1 1.7 ± 1.3
Albumin (g/dl) 2.4 ± 0.8 2.4 ± 0.8
Fluid balance (ml/24 h) 2,589 ± 2,153 2,793 ± 2,085
  1. Data are expressed as median (IQR), mean (± SD), or counts (percentage). APACHE, Acute Physiology and Chronic Health Evaluation; SOFA, Sequential Organ Failure Assessment.