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Table 3 Differences in numbers of patients achieving optimal peak or high Cmin concentrations

From: Revisiting the loading dose of amikacin for patients with severe sepsis and septic shock

Regimen Peak >64 μg/ml
n (%)
Cmin>5 μg/ml
n (%)
15 mg/kg TBW 7 (9) 29 (39)
25 mg/kg TBW 50 (72) 39 (52)
30 mg/kg TBW 59 (79) 43 (58)
25 mg/kg IBW 35 (47) 39 (52)
25 mg/kg DW 42 (56) 39 (52)
  1. Doses were calculated by using total body weight (TBW), ideal body weight (IBW), or IBW with correction factors (DW) for extreme body mass indexes.