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Table 3 Differences in numbers of patients achieving optimal peak or high Cmin concentrations

From: Revisiting the loading dose of amikacin for patients with severe sepsis and septic shock

Regimen

Peak >64 μg/ml

n (%)

Cmin>5 μg/ml

n (%)

15 mg/kg TBW

7 (9)

29 (39)

25 mg/kg TBW

50 (72)

39 (52)

30 mg/kg TBW

59 (79)

43 (58)

25 mg/kg IBW

35 (47)

39 (52)

25 mg/kg DW

42 (56)

39 (52)

  1. Doses were calculated by using total body weight (TBW), ideal body weight (IBW), or IBW with correction factors (DW) for extreme body mass indexes.