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Table 2 Pharmacokinetic parameters and comparison with previous literature using cefepime dosage of 2 g q 12 h.

From: Prospective monitoring of cefepime in intensive care unit adult patients

Parameters and time of calculation Mean reported values ± SD
  Present study Barbhaiya et al. 3[45] Sampol et al.4[50] Bonapace et al.4[44]
First dose (17 patients)     
   T1/2β (h) 4.03 ± 3.19 NS 2.45 ± 0.56 2.8 ± 0.6
   CMax (mg/l) 1 105 ± 22 132 ± 21 NS 102 ± 15 5
   CMin (mg/l)1 7.6 ± 12 NS NS NS
   AUC (mg.h/liter) 370 ± 360 268 ± 27 217 ± 34 224 ± 59
   MRT (h) 5.1 ± 4.64 2.56 ± 0.31 NS NS
   Clearance (liter/h.kg) 1,2 0.130 ± 0.077 NS 0.152 ± 0.025 0.1 ± 0.03
   Vβ (liter/kg) 0.513 ± 0.180 NS NS NS
   VSS (liter/kg) 0.413 ± 0.118 NS 0.36 ± 0.1 0.43 ± 0.1
Steady state (11 patients)     
   T1/2β (h) 4.33 ± 4.32 Not available 2.62 ± 0.53 Not available
   CMax (mg/l) 1 97 ± 8   NS  
   CMin (mg/l)1 2.68 ± 3.06   NS  
   AUC (mg.h/liter)1 226 ± 107   262 ± 57  
   MRT (h) 5.3 ± 5.9   NS  
   Clearance (liter/h.kg) 0.131 ± 0.084   0.133 ± 0.029  
   Vβ (liter/kg) 0.513 ± 0.180   NS  
   VSS (liter/kg) 0.413 ± 0.118   0.35 ± 0.1  
  1. CMax and CMIN, maximal and minimal plasma concentrations at the end of drug infusion and just before the next infusion, respectively; AUC, area under the curve; MRT, mean residence time; NS, not specified; T1/2β, terminal plasma half-life; Vβ, initial volume of distribution; VSS, volume of distribution at steady state
  2. 1only patients with 2 g q 12 h (without two cases with dose adjustment at steady state)
  3. 2extrapolated to infinity for the first PK
  4. 3in normal volunteers
  5. 4in burn patients