Skip to main content

Table 2 Pharmacokinetic parameters and comparison with previous literature using cefepime dosage of 2 g q 12 h.

From: Prospective monitoring of cefepime in intensive care unit adult patients

Parameters and time of calculation

Mean reported values ± SD

 

Present study

Barbhaiya et al. 3[45]

Sampol et al.4[50]

Bonapace et al.4[44]

First dose (17 patients)

    

   T1/2β (h)

4.03 ± 3.19

NS

2.45 ± 0.56

2.8 ± 0.6

   CMax (mg/l) 1

105 ± 22

132 ± 21

NS

102 ± 15 5

   CMin (mg/l)1

7.6 ± 12

NS

NS

NS

   AUC (mg.h/liter)

370 ± 360

268 ± 27

217 ± 34

224 ± 59

   MRT (h)

5.1 ± 4.64

2.56 ± 0.31

NS

NS

   Clearance (liter/h.kg) 1,2

0.130 ± 0.077

NS

0.152 ± 0.025

0.1 ± 0.03

   Vβ (liter/kg)

0.513 ± 0.180

NS

NS

NS

   VSS (liter/kg)

0.413 ± 0.118

NS

0.36 ± 0.1

0.43 ± 0.1

Steady state (11 patients)

    

   T1/2β (h)

4.33 ± 4.32

Not available

2.62 ± 0.53

Not available

   CMax (mg/l) 1

97 ± 8

 

NS

 

   CMin (mg/l)1

2.68 ± 3.06

 

NS

 

   AUC (mg.h/liter)1

226 ± 107

 

262 ± 57

 

   MRT (h)

5.3 ± 5.9

 

NS

 

   Clearance (liter/h.kg)

0.131 ± 0.084

 

0.133 ± 0.029

 

   Vβ (liter/kg)

0.513 ± 0.180

 

NS

 

   VSS (liter/kg)

0.413 ± 0.118

 

0.35 ± 0.1

 
  1. CMax and CMIN, maximal and minimal plasma concentrations at the end of drug infusion and just before the next infusion, respectively; AUC, area under the curve; MRT, mean residence time; NS, not specified; T1/2β, terminal plasma half-life; Vβ, initial volume of distribution; VSS, volume of distribution at steady state
  2. 1only patients with 2 g q 12 h (without two cases with dose adjustment at steady state)
  3. 2extrapolated to infinity for the first PK
  4. 3in normal volunteers
  5. 4in burn patients