From: Prospective monitoring of cefepime in intensive care unit adult patients
Parameters and time of calculation | Mean reported values ± SD | |||
---|---|---|---|---|
Present study | Barbhaiya et al. 3[45] | Sampol et al.4[50] | Bonapace et al.4[44] | |
First dose (17 patients) | ||||
T1/2β (h) | 4.03 ± 3.19 | NS | 2.45 ± 0.56 | 2.8 ± 0.6 |
CMax (mg/l) 1 | 105 ± 22 | 132 ± 21 | NS | 102 ± 15 5 |
CMin (mg/l)1 | 7.6 ± 12 | NS | NS | NS |
AUC (mg.h/liter) | 370 ± 360 | 268 ± 27 | 217 ± 34 | 224 ± 59 |
MRT (h) | 5.1 ± 4.64 | 2.56 ± 0.31 | NS | NS |
Clearance (liter/h.kg) 1,2 | 0.130 ± 0.077 | NS | 0.152 ± 0.025 | 0.1 ± 0.03 |
Vβ (liter/kg) | 0.513 ± 0.180 | NS | NS | NS |
VSS (liter/kg) | 0.413 ± 0.118 | NS | 0.36 ± 0.1 | 0.43 ± 0.1 |
Steady state (11 patients) | ||||
T1/2β (h) | 4.33 ± 4.32 | Not available | 2.62 ± 0.53 | Not available |
CMax (mg/l) 1 | 97 ± 8 | NS | ||
CMin (mg/l)1 | 2.68 ± 3.06 | NS | ||
AUC (mg.h/liter)1 | 226 ± 107 | 262 ± 57 | ||
MRT (h) | 5.3 ± 5.9 | NS | ||
Clearance (liter/h.kg) | 0.131 ± 0.084 | 0.133 ± 0.029 | ||
Vβ (liter/kg) | 0.513 ± 0.180 | NS | ||
VSS (liter/kg) | 0.413 ± 0.118 | 0.35 ± 0.1 |