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Table 1 Clinical and microbiological features of the study population (10 females and 11 males; median age 55.1 years, range 21.8 to 81.2)

From: Prospective monitoring of cefepime in intensive care unit adult patients

Reason for ICU admission Underlying disease SAPS II score Weight
(Kg)
ClCr Presumed pathogens MIC
(mg/l)
Cardiovascular surgery 1 Coronary artery disease 38 75 17.8   
Multiple trauma Bipolar disorder 33 75 139.3 E. coli 0.024
Thoracic surgery 2 Non-specific interstitial pneumonia 33 85 126.6   
Abdominal surgery 3 Abdominal aortic aneurysms 26 75 51   
Multiple trauma Chronic obstructive pulmonary disease 23 86 63.4 S. aureus 2
Abdominal surgery Abdominal aortic aneurysms 32 85 32.9   
Cardiovascular surgery Aortic stenosis 47 63 62.2   
Acute respiratory failure 4 Obesity stage II 24 120 135.5 S. pneumoniae 0.75
Neurosurgery Cerebral arterio-venous malformation 50 53 166.9 E. coli 0.04
Cardiovascular surgery Myeloproliferative disorder 52 65 79.6 S. pneumoniae 0.047
Multiple trauma None 42 70 133.5 P. aeruginosa 4
Cardiovascular surgery Aortic bicuspidy 9 68 101.9   
Acute respiratory failure 1 Coronary artery disease 51 60 12   
Neurosurgery None 23 40 161 P. aeruginosa 4
Multiple trauma Diabetes mellitus 22 58 92.1   
Cardiovascular surgery Coronary artery disease 24 78 59.8   
Acute respiratory failure 4 Myeloproliferative disorder 69 52 95.5 S. pneumoniae 1
Cardiovascular surgery Coronary artery disease 33 47 115.1   
Multiple trauma None 24 62 142.1   
Ear-nose and throat surgery Pharynx carcinoma 43 60 87.7   
Neurosurgery High blood pressure 58 100 121.8 H. influenzae 1
  1. ClCr, creatinine clearance at inclusion, as determined by the Cockcroft-Gault equation; E. coli, Escherichia coli; H. influenza, Haemophilus influenza; MIC, minimal inhibitory concentration; P. aeruginosa, Pseudomonas aeruginosa; S. aureus, Staphylococcus aureus;S. pneumonia, Streptococcus pneumoniae;
  2. 1Patients who developed drug accumulation and symptoms compatible with neurological toxicity.
  3. 2Patient suffering a further episode of bronchoaspiration; switched to amoxicillin-clavulanate during follow-up.
  4. 3Patient died eight days after leaving the ICU from multiorgan failure. Autopsy revealed an ischemic colitis with intra-abdominal steatonecrosis. Patient was also treated with metronidazole for the presence of Clostridium difficile in stool cultures.
  5. 4Patients eventually switched to levofloxacin as a treatment of choice of penicillin intermediate-resistant Streptococcus pneumoniae.