Table 2 Systolic, diastolic and mean blood flow velocities (cm/s) and pulsatility indices before and after administration of acetazolamide in control persons and in patients with sepsis-associated encephalopathy

0

85.4 ± 20.7

85.9 ± 13.7

0.94

5

99.6 ± 31.6

114.1 ± 20.5

0.15

10

96.5 ± 24.2

118.5 ± 19.5

< 0.05

15

101.9 ± 27.1

124.4 ± 17.5

< 0.05

20

102.0 ± 27.7

121.9 ± 17.4

< 0.05

Diastolic blood flow velocity

0

32.5 ± 12.3

45.6 ± 8.8

< 0.01

5

35.9 ± 12.5

61.9 ± 12.6

< 0.001

10

40.1 ± 13.3

64.2 ± 13.9

< 0.001

15

43.2 ± 17.4

64.4 ± 11.7

< 0.001

20

40.0 ± 12.6

80.4 ± 14.3

< 0.001

Mean blood flow velocity

0

47.9 ± 14.5

58.2 ± 12.0

< 0.05

5

55.4 ± 18.2

77.8 ± 17.1

< 0.01

10

56.4 ± 16.0

79.3 ± 16.6

< 0.001

15

59.4 ± 19.4

64.4 ± 11.7

< 0.01

20

58.7 ± 17.5

80.4 ± 14.3

< 0.001

Pulsatility index

0

1.15 ± 0.35

0.85 ± 0.20

< 0.01

5

1.21 ± 0.26

0.80 ± 0.16

< 0.001

10

1.01 ± 0.32

0.70 ± 0.16

< 0.01

15

0.98 ± 0.34

0.76 ± 0.15

< 0.05

20

1.06 ± 0.24

0.74 ± 0.14

< 0.01