Table 1 Characteristics of the surviving and non-surviving study patients. Categorical variables are presented as frequencies with percents and other variables as medians with 25th to 75th percentiles
From: Matrix-metalloproteinase-2, -8 and -9 in serum and skin blister fluid in patients with severe sepsis
All (n = 44) | Survivors (n = 33) | Non-survivors (n = 11) | P | |
|---|---|---|---|---|
Male sex | 29 (57%) | 20 (60%) | 9 (80%) | 0.31 |
Age, years | 63 (53-71) | 61 (56-66) | 71 (62-74) | 0.06 |
Body mass index, kg/m2 | 26 (24-32) | 28 (23-33) | 26 (24-27) | 0.17 |
Chronic diseases | ||||
-ischemic heart disease | 9 (20%) | 5 (15%) | 4 (36%) | |
-diabetes | 10 (23%) | 9 (27%) | 1 (9%) | |
-chronic obstructive pulmonary disease | 5 (11%) | 4 (12%) | 1 (9%) | |
-asthma | 4 (9%) | 4 (12%) | 0 | |
Focus of infection | ||||
-lungs | 18 (41%) | 13 (39%) | 5 (45%) | |
-intra-abdominal | 16 (36%) | 12 (36%) | 4 (36%) | |
-urinary | 1 (2%) | 1 (3%) | 0 | |
-primary blood | 3 (7%) | 2 (6%) | 1 (9%) | |
-other | 6 (14%) | 5 (15%) | 1 (9%) | |
APACHE II score | 26 (22-30) | 24 (22-27) | 31 (26-37) | 0.005 |
Maximum SOFA score | 9.5 (7-16) | 8 (7-11) | 16 (11-20) | 0.003 |
Multiple organ failure | 30 (68%) | 20 (60%) | 10 (90%) | <0.001 |
Length of stay (at the intensive care unit) | 6.6 (4-12) | 6 (4-8) | 11 (6-14) | 0.16 |
Surgical admission | 25 (57%) | 18 (55%) | 7 (63%) | <0.001 |
Hydrocortisone therapy | 32 (73%) | 22 (67%) | 10 (90%) | <0.001 |
Noradrenaline maximum rate, μg/kg/min | 38 (86%) 0.42(0.19-1) | 27 (82%) 0.25(0.09-0.43) | 11 (100%) 0.96 (0.53-1.80) | 0.13 0.005 |
Adrenaline | 1 (2%) | 1(3%) | 0 | 0.56 |
Vasopressin and analogues | 6 (14%) | 3 (9%) | 3 (27%) | 0.15 |
Activated protein C | 6 (14%) | 3 (9%) | 3 (27%) | 0.13 |