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Figure 3 | Critical Care

Figure 3

From: Renal hypoperfusion and impaired endothelium-dependent vasodilation in an animal model of VILI: the role of the peroxynitrite-PARP pathway

Figure 3

Effects of WW85 or PJ-34 on hemodynamics. Rats received lipopolysaccharide (10 mg/kg) intratracheally at time 0, followed by mechanical ventilation. n = 8/group in low tidal volume (Vt)+Vehicle, high Vt+Vehicle, high Vt+WW85, n = 7/group in high Vt+PJ-34. (a) Mean arterial pressures. * P < 0.05 high Vt+Vehicle vs. all at time 180 and 210 minutes. (b) Cardiac output over time. (c) Renal blood flow at time t = 0 and t = 180 minutes. † P < 0.05 high Vt+Vehicle vs. low Vt+Vehicle and high Vt+Vehicle vs. high Vt+PJ-34. n = 5/group. Values represent median (interquartile range).

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Critical Care

ISSN: 1364-8535