From: Mechanical ventilation with high tidal volume induces inflammation in patients without lung disease
 | High V T Group | Low V T Group | ||
---|---|---|---|---|
Time | Zero | 12 h | Zero | 12 h |
VT (PBW) (ml) | 11.3 ± 0.8** | 11.9 ± 0.9* | 6.2 ± 0.6 | 6.2 ± 0.7 |
Peak Pressure (cmH2O) | 29.80 ± 8.74** | 29.6 ± 7.39** | 17.90 ± 2.80 | 17.60 ± 3.34 |
Plateau Pressure (cmH2O) | 28.90 ± 8.71** | 28.60 ± 7.32** | 17.10 ± 3.03 | 16.70 ± 3.26 |
PEEP (cmH2O) | 4.30 ± 0.48 | 4.30 ± 0.48 | 4.50 ± 0.52 | 4.50 ± 0.52 |
Ventilatory rate (bpm) | 18.6 ± 1.4 * | 18.7 ± 1.4* | 20.7 ± 2.5 | 21.3 ± 2.2 |
FIO2 (%) | 52.50 ± 25.41 | 48.50 ± 19.58 | 41.00 ± 2.10 | 41.00 ± 2.10 |
pH | 7.38 ± 0.04 | 7.41 ± 0.06 | 7.39 ± 0.05 | 7.40 ± 0.04 |
PaO2 (mmHg) | 143.60 ± 30.52 | 133.70 ± 32.92 | 146.00 ± 81.83 | 119.80 ± 28.76 |
PaCO2 (mmHg) | 34.40 ± 7.32 | 26.60 ± 5.60 | 30.29 ± 8.28 | 31.45 ± 7.18 |
HCO3 (mmol/L) | 20.80 ± 6.01 | 17.89 ± 5.56 | 19.71 ± 4.58 | 21.42 ± 5.56 |
SaO2 (%) | 98.00 ± 2.58 | 98.30 ± 2.16 | 97.60 ± 2.27 | 97.90 ± 2.18 |
PaO2/FIO2 | 307 ± 101 | 298 ± 105 | 358 ± 207 | 293 ± 74 |