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Table 1 Baseline characteristics of patients with and without sepsis

From: Effect of dexmedetomidine versus lorazepam on outcome in patients with sepsis: an a priori-designed analysis of the MENDS randomized controlled trial

  Patients with sepsis Patients without sepsis
Variable DEX (n = 31) LZ (n = 32) DEX (n = 20) LZ (n = 19)
Age 60 (46 to 65) 58 (44 to 66) 61 (50 to 68) 60 (52 to 67)
Males 58% 41% 57% 53%
APACHE II 30 (26 to 34) 29 (24 to 32) 27 (20 to 31) 25 (20 to 30)
SOFA score 10 (9 to13) 9 (8 to 12) 9 (8 to 12) 8 (7 to 9)
IQCODE at enrollment 3 (3 to 3) 3 (3 to 3) 3 (3 to 3) 3 (3 to 3)
Medical ICU 77% 81% 62% 47%
Surgical ICU 23% 19% 38% 53%
Pre-enrollment lorazepam (mg) 1.5 (0 to 5) 0 (0 to 4) 0 (0 to 4) 0 (0 to 2)
Enrollment RASS -3 (-4 to -2) -4 (-4 to -3) -3 (-4 to 0) -3 (-4 to -1)
SIRS criteria     
Temperature (Fahrenheit) 37.5 (37 to 38.3) 38 (37.2 to 38.6) 36.7 (35.8 to 37.8) 37.2 (36.2 to 38.3)
White blood count (103/μL) 12.5 (6.6 to 21.7) 12.5 (7.7 to 18.8) 14.6 (8.9 to17.9) 10 (7.5 to14)
Systolic BP
(mm Hg)
88 (78 to 100) 83 (79 to 100) 92 (90 to 100) 90 (80 to110)
Heart rate
(per minute)
113 (100 to 134) 119 (96 to 130) 80 (65 to123) 107 (99 to 126)
Respiratory rate 26 (20 to 33) 33 (27 to 39) 20 (15 to24) 24 (20 to28)
Organ dysfunction at enrollment     
PaO2/FiO2 ratio 128 (105 to 209) 126 (94 to 198) 127 (72 to 211) 145 (81 to 223)
Creatinine (mg/dL) 1.7 (0.8 to 2.9) 1.0 (0.8 to 1.8) 1.2 (1.0 to 1.7) 0.9 (0.8 to 1.4)
Vasopressors 32% 56% 19% 5%
Bilirubin (mg/dL) 0.5 (0.4 to 0.8) 0.9 (0.4 to 1.8) 0.6 (0.5 to 1.6) 0.6 (0.4 to 1.1)
Platelets (103/μL) 176 (61 to 304) 183 (107 to 266) 186 (101 to242) 145 (114 to 242)
  1. Median (interquartile range) unless otherwise noted.
  2. APACHE II, Acute Physiology and Chronic Health Evaluation II; BP, Blood pressure; DEX, dexmedetomidine; FiO2, fraction of inspired oxygen; IQCODE, Informant Questionnaire on Cognitive Decline in the Elderly; LZ, lorazepam; PaO2, partial pressure of arterial oxygen; RASS, Richmond Agitation-Sedation Scale; SIRS, Systemic Inflammatory Response Syndrome; SOFA, Sequential Organ Failure Assessment.