Alveolar fluid clearance in healthy pigs and influence of positive end-expiratory pressure

Table 1 Extravascular lung water and respiratory and hemodynamic parameters.

	Baseline	0	60 minutes	120 minutes	180 minutes	240 minutes
EVLW (ml)
SE	286 (72) ^a	421 (93)	395 (81)	356 (57)	346 (58)	344 (63)
LE	225 (30) ^a	458 (42)	415 (34)	387 (27)	354 (40)	331 (45)
SE+PEEP	309 (80) ^a	446 (64)	383 (60)	371 (70)	367 (75)	363 (73)
LE+PEEP	269 (37) ^a	491 (56) ^b	436 (28) ^b	389 (54)	366 (43)	349 (46)
PaO ₂ /FiO ₂
SE	346 (148) ^b	167 (91)	193 (95)	204 (121)	216 (134)	221 (141)
LE	416 (128) ^b	100 (36)	96 (49)	118 (44)	169 (62)	183 (54)
SE+PEEP	269 (156)	420 (74) ^c	432 (89) ^c	424 (107) ^c	403 (127) ^c	425 (121) ^c
LE+PEEP	437 (69)	202 (93) ^d	262 (144) ^d	401 (141) ^d	505 (29) ^d	539 (27) ^d
Pplat (mmHg)
SE	11.8 (2.7) ^a	15.3 (1.7)	15.4 (2.2)	15.3 (1.9)	15.1 (2.2)	14.9 (2.0)
LE	10.8 (2.3) ^a	17.1 (1.5)	16.2 (3.0)	15.2 (1.9)	15.2 (2.3)	15.4 (2.4)
SE+PEEP	14.8 (3.4) ^a	23.4 (3.1) ^e	23.2 (1.6) ^e	23.2 (1.7) ^e	23.2 (1.7) ^e	23.1 (1.8) ^e
LE+PEEP	14.4 (4.5) ^a	27.4 (7.4) ^f	26.6 (4.9) ^f	26.9 (4.7) ^f	25.8 (4.3) ^f	25.8 (4.7) ^f
MAP(mmHg)
SE	68.2 (9.5)	68.2 (9.3) ^a	76.9 (12.3)	82.7 (10.5)	84.3 (9.6)	87.3 (10.8)
LE	77.2 (10.7)	77.0 (5.1)	80.2 (6.8)	77.4 (5.7)	81.2 (10.7)	82.4 (12.8)
SE+PEEP	59.0 (8.3)	61.7 (5.5)	69.8 (8.2)	75.0 (9.6)	76.2 (12.7)	77.4 (13.3)
LE+PEEP	70.4 (13.8) ^g	52.4 (10.5)	63.2 (5.4)	66.8 (4.8)	64.4 (4.8)	64.7 (5.0)
CO (L/min)
SE	3.7 (0.9)	3.9 (1.0)	4.5 (1.2)	4.7 (0.9)	4.6 (0.9)	4.5 (0.9)
LE	3.9 (1.2)	3.9 (0.9)	4.6 (1.4)	4.5 (1.2)	4.1 (0.9)	3.9 (0.9)
SE+PEEP	3.9 (0.7)	4.7 (0.8)	4.4 (0.9)	4.2 (0.8)	4.3 (0.9)	4.1 (1.0)
LE+PEEP	3.8 (1.1) ^b	3.0 (1.0) ^d	3.9 (0.8) ^d	3.7 (0.9) ^d	3.4 (0.8) ^d	3.2 (0.7) ^d

Data are expressed as mean (SD).
a Statistically significant differences with subsequent time points (P < 0.01).
b Statistically significant differences with subsequent time points (P < 0.05).
c Statistically significant differences between SE and SE + PEEP groups (P < 0.05).
d Statistically significant differences between LE and LE + PEEP groups (P < 0.05).
e Statistically significant differences between SE and SE + PEEP groups (P < 0.01).
f Statistically significant differences between LE and LE + PEEP groups (P < 0.01).
g Statistically significant differences between baseline and time 0 (P < 0.05). CO, cardiac output; EVLW, extravascular lung water; LE, large edema; LE + PEEP, large edema + positive end-expiratory pressure; MAP, mean arterial pressure; Pplat, plateau pressure; SE, small edema; SE + PEEP, small edema + positive end-expiratory pressure.

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