Ischemia as a possible effect of increased intra-abdominal pressure on central nervous system cytokines, lactate and perfusion pressures

Table 2 Changes of cerebral and spinal perfusion pressures during the four experimental phases (T1 to T4).

	T1 (baseline)		T2 (IAP = 20 mmHg)		T3 (IAP = 45 mmHg)		T4 (desufflation)
MAP	85.8 ± 9.62		79.8 ± 11.7		86.8 ± 15.73		84.6 ± 7.37
p		0.186 (T1 vs. T2)		0.297(T2 vs. T3)		0.625 (T3 vs. T4)
ICP	18.7 ± 7.57		25.4 ± 7.79		26.8 ± 9.17		15.3 ± 3.65
p		*<0.001* (T1 vs. T2)		0.485 (T2 vs. T3)		*<0.001* (T3 vs. T4)
CPP	67.1 ± 13.81		54.4 ± 9.77		60 ± 16.54		69.3 ± 8.38
p		*0.013* (T1 vs. T2)		0.392 (T2 vs. T3)		0.057 (T3 vs. T4)
ISP	13.2 ± 3.26		25.4 ± 8.36		22.3 ± 8		12.3 ± 3.86
p		*0.001* (T1 vs. T2)		0.375 (T2 vs. T3)		*0.005* (T3 vs. T4)
SPP	72.6 ± 10.95		54.4 ± 10.6		64.5 ± 21.57		72.3 ± 7.42
p		*0.002* (T1 vs. T2)		0.198 (T2 vs. T3)		0.235 (T3 vs. T4)

CPP is calculated as mean arterial pressure (MAP) minus intracranial pressure (ICP), while SPP as MAP minus intraspinal pressure (ISP). All pressures are displayed as mean ± SD and expressed as mmHg. Statistical significances (p < 0.05) are marked with bold. IAP: intra-abdominal pressure.

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