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Table 1 Changes of concentrations ofCNS ischemia indicators during thefour experimental phases (T1 to T4).

From: Ischemia as a possible effect of increased intra-abdominal pressure on central nervous system cytokines, lactate and perfusion pressures

 

T1

(baseline)

T2

(IAP = 20 mmHg)

T3 (IAP = 45 mmHg)

T4

(desufflation)

IL-6 Blood

635 (226)

755 (254.8)

584 (176)

676.5 (207.5)

p

 

0.043 (T1 vs. T2)

0.345 (T2 vs. T3)

1.00 (T3 vs. T4)

 

IL-6 CSF

611.5 (328.8)

917.5 (245.3)

822 (291)

825 (232)

p

 

0.028 (T1 vs. T2)

0.043 (T2 vs. T3)

0.715 (T3 vs. T4)

 

TNFa Blood

560 (798)

1070.5 (446.5)

710 (647)

854 (597)

p

 

0.012 (T1 vs. T2)

0.499 (T2 vs. T3)

0.612 (T3 vs. T4)

 

TNFa CSF

118.5 (160.3)

245 (331)

195 (396.5)

284.5 (497.5)

p

 

0.068 (T1 vs. T2)

0.463 (T2 vs. T3)

0.345 (T3 vs. T4)

 

Lac Blood

0.1 (1.85)

1.15 (1.3)

1.15 (1.375)

1.15 (1)

p

 

0.752 (T1 vs. T2)

0.496 (T2 vs. T3)

0.6 (T3 vs. T4)

 

Lac CSF

1.4 (1.7)

2.3 (1.3)

1.6 (2.8)

1.9 (1.6)

p

 

0.017 (T1 vs. T2)

0.237 (T2 vs. T3)

0.109 (T3 vs. T4)

 
  1. CSF: cerebrospinal fluid; IL-6: interleukin 6, Lac: lactate, TNFa: tumor necrosis factor alpha. Data are displayed as median and interquartile range in parentheses. IL-6 and TNFa are expressed as pg/ml and lactate as mmol/L. Statistical significances (p < 0.05) are marked in bold. IAP, intra-abdominal pressure.