Table 2 Factor V allele and genotype frequencies in individuals with systemic inflammatory response syndromeand sepsis compared to controls
Controls N = 8147 | All cases N = 1249 | ICU cohort N = 237 | G1 cohort N = 315 | G2 cohort N = 534 | IPD cohort N = 163 | ||
|---|---|---|---|---|---|---|---|
Number and frequency of the FV alleles (%) | G A | 15648 (96.0) 646 (4.0) | 2396 (95.9) 102 (4.1) | 446 (94.1) 28 (5.9) | 607 (96.3) 23 (3.7) | 1025 (95.9) 43 (4.0) | 318 (97.5) 8 (2.5) |
Allele P value | -- | Chi Sq = 0.0517; df = 1; P = 0.820 | Chi.Sq = 4.0156; df = 1; P = 0.0451 | Chi.Sq = 0.0856; df = 1; P = 0.7699 | Chi.Sq = 0.004; df = 1; P = 0.984 | Chi.Sq = 1.5506; df = 1; P = 0.2131 | |
OR (95% CI) | -- | 1.03 (0.83 to 1.28) | 1.52 (1.03 to 2.25) | 0.97 (0.63 to 1.49) | 0.92 (0.65 to 1.30) | 0.63 (0.31 to 1.30) | |
Adj. OR (95% CI)* | -- | 1.02 (0.82 to 1.29) | 1.66 (1.11 to 2.49) | 0.97 (0.63 to 1.50) | 0.92 (0.65 to 1.30) | 0.63 (0.31 to 1.30) | |
Allelic P value** | -- | 0.871 | 0.014 | 0.897 | 0.626 | 0.216 | |
Number and frequency of the FV genotype (%) | GG | 7518 (92.3) | 1150 (92.1) | 209 (88.2) | 292 (92.7) | 494 (92.5) | 155 (95.1) |
GA | 612 (7.5) | 96 (7.7) | 28 (11.8) | 23 (7.3) | 37 (6.9) | 8 (4.9) | |
AA | 17 (0.2) | 3 (0.2) | 0 | 0 | 3 (0.6) | 0 | |
Genotypic P value | -- | 0.952 | 0.04 | 0.71 | 0.3 | 0.23 | |
OR (95% CI)*** Carrier vs. non-carrier | -- | 1.03 (0.83 to 1.28) | 1.60 (1.07 to 2.39) | 0.94 (0.61 to 1.45) | 0.97 (0.69 to 1.35) | 0.62 (0.30 to 1.26) | |
Adj. OR (95% CI)* Carrier vs. non-carrier | -- | 1.03 (0.83 to 1.29) | 1.62 (1.08 to 2.42) | 0.95 (0.61 to 1.46) | 0.97 (0.69 to 1.36) | 0.62 (0.30 to 1.27) | |
Genotypic P value** | -- | 0.791 | 0.019 | 0.799 | 0.847 | 0.189 |