| Total N = 259 | Sepsis N = 127 | Severe sepsis N = 75 | Septic shock N = 57 | P value |
---|---|---|---|---|---|
Age yrs, mean (SD) | 58.1 (18.6) | 54.7 (18.6) | 61.0 (17.3) | 61.7 (19.2) | <0.05a,b |
Male, n (%) | 180 (69.5) | 88 (69.3) | 55 (73.3) | 37 (64.9) | ns |
WBC (*103/mm3), mean (SD) | 14.0 (9.5) | 14.1 (8.1) | 15.2 (10.9) | 12.8 (11.0) | ns |
CRP (mg/dL), mean (SD) | 11.8 (9.1) | 10.0 (8.5) | 11.4 (9.3) | 15.6 (9.5) | <0.001b |
IL-6 (pg/mL), mean (SD) | 33,543 (136,974) | 8,398 (47,705) | 8,176 (37,975) | 118,435 (264,819) | <0.001b,c |
Gram positive bacteremia, n (%) | 168 (64.9) | 92 (72.4) | 51 (68.0) | 25 (43.9) | <0.0005d <0.01e |
Gram negative bacteremia, n (%) | 70 (27.0) | 28 (22.0) | 17 (22.7) | 25 (43.9) | <0.005d <0.01e |
Both of Gram positive and negative bacteremia*, n (%) | 15 (5.8) | 4 (3.1) | 4 (5.3) | 7 (12.3) | <0.05d |
Fungemia*, n (%) | 7 (2.7) | 3 (2.3) | 3 (4.0) | 1 (1.8) | ns |
Bacteremia caused by multiple organisms, n (%) | 16 (6.2) | 4 (3.1) | 4 (5.3) | 8 (14.0) | <0.01d |
Length of ICU stay (day), mean (SD) | 19.4 (21.7) | 20.6 (22.4) | 17.4 (17.7) | 19.5 (24.9) | ns |
Mortality (%) | 31.3 | 20.5 | 36.0 | 49.1 | <0.001d |