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Table 1 Patients' characteristics, white blood cell count, C-reactive protein and interleukin-6 blood level and mortality

From: Gram-negative bacteremia induces greater magnitude of inflammatory response than Gram-positive bacteremia

 

Total

N = 259

Sepsis

N = 127

Severe sepsis

N = 75

Septic shock

N = 57

P value

Age yrs, mean (SD)

58.1

(18.6)

54.7

(18.6)

61.0

(17.3)

61.7

(19.2)

<0.05a,b

Male, n (%)

180

(69.5)

88

(69.3)

55

(73.3)

37

(64.9)

ns

WBC (*103/mm3), mean (SD)

14.0

(9.5)

14.1

(8.1)

15.2

(10.9)

12.8

(11.0)

ns

CRP (mg/dL), mean (SD)

11.8

(9.1)

10.0

(8.5)

11.4

(9.3)

15.6

(9.5)

<0.001b

IL-6 (pg/mL), mean (SD)

33,543

(136,974)

8,398

(47,705)

8,176

(37,975)

118,435

(264,819)

<0.001b,c

Gram positive bacteremia, n (%)

168

(64.9)

92

(72.4)

51

(68.0)

25

(43.9)

<0.0005d

<0.01e

Gram negative bacteremia, n (%)

70

(27.0)

28

(22.0)

17

(22.7)

25

(43.9)

<0.005d

<0.01e

Both of Gram positive and negative bacteremia*, n (%)

15

(5.8)

4

(3.1)

4

(5.3)

7

(12.3)

<0.05d

Fungemia*, n (%)

7

(2.7)

3

(2.3)

3

(4.0)

1

(1.8)

ns

Bacteremia caused by multiple organisms, n (%)

16

(6.2)

4

(3.1)

4

(5.3)

8

(14.0)

<0.01d

Length of ICU stay (day), mean (SD)

19.4

(21.7)

20.6

(22.4)

17.4

(17.7)

19.5

(24.9)

ns

Mortality (%)

31.3

20.5

36.0

49.1

<0.001d

  1. WBC, white blood cell count; CRP, C-reactive protein; IL-6, interleukin-6. *One case overlapping because Gram-positive bacteria and fungi were detected. aWith unpaired Student's T test, between sepsis group and severe sepsis group. bWith unpaired Student's T test, between sepsis group and septic shock group. c With unpaired Student's T test, between severe sepsis group and septic shock group. d With Chi square test, between sepsis group and septic shock group. e With Chi square test, between severe sepsis group and septic shock group.