Figure 1From: Renin-angiotensin system activation correlates with microvascular dysfunction in a prospective cohort study of clinical sepsisCirculating RAS mediators are prevalent in the septic circulation. Plasma renin activity (Panel A) and the plasma concentration of angiotensin II (Panel B) were assessed in control (n = 10) and septic subjects. At eight hours following the recognition of organ dysfunction, both PRA and Ang II were elevated in septic subjects (n = 12). Despite resuscitation to clinical endpoints, median values for PRA (7.4 ng/mL/hr, range 0.1 to 49.7 ng/mL/hr) and Ang II (29.8 pg/mL, range 3.1 to 242.8 pg/mL) remained elevated at 24 hours (n = 30). Data depict median, interquartile range, and range for each column. * P < 0.05, ** P < 0.01 compared to control, Kruskal-Wallis test, and Dunn's Multiple Comparison post-hoc test.Back to article page