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Table 2 Characteristics of the intervention:

From: Effect of different components of triple-H therapy on cerebral perfusion in patients with aneurysmal subarachnoid haemorrhage: a systematic review

Reference Triple-H components Composition Complications
  type Prophylactic/Therapeutic Intervention group Control group Intracranial
Int/
no Int
Systemic
Int/
no Int
Ekelund, 2002 [18] isovolemic hemodilution or hypervolemic hemodilution Therapeutic -Isovolemic: Venasection with simultaneous infusion of 70% dextran and 4% albumin in equal volumes
-Hypervolemic (after isovolemic): Autotransfusion and infusion of 70% dextran and 4% albumin
- unknown unknown
Mori, 1995 [14] hypervolemic hemodilution Therapeutic 500 ml human albumin solution, 500 ml low molecular dextran per day 900 ml 10% glycerol per day 0%/unknown 4%/unknown
Yamakami, 1987 [21] hypervolemia Prophylactic 500 ml 5% albumin in 30 minutes - unknown unknown
Lennihan, 2000 [13] hypervolemia Prophylactic 250 ml 5% albumin in two hours 80 ml 5% dextrose and 0.9% saline in one hour 15%/17% 7%/5%
Tseng, 2003 [23] hypervolemia Therapeutic 2 ml/kg 23.5% saline in 20 minutes - unknown unknown
Jost, 2005 [22] hypervolemia Therapeutic 15 ml/kg 0.9% saline in one hour - unknown unknown
Muizelaar, 1986 [25] hypertension Therapeutic -Phenylephrine (mean MAP increase of 33 mmHg)
-hypervolemia with Ht around 32%
- 0% 0%
Touho, 1992 [20] hypertension Both Continuous infusion of dopamine 7 to 15 μg/kg/min (mean MAP increase of 22 mmHg) - unknown unknown
Darby, 1994 [24] hypertension Therapeutic dopamine 6.4 to 20 μg/kg/min (mean MAP increase of 21 mmHg) - unknown unknown
Origitano, 1990 [15] Triple-H Prophylactic -Venasection to Ht of 30 in increments of 150 to 250 ml every eight hours within 12 to 24 hours
-infusion of 250 to 500 ml 5% albumin every six hours
-dopamine or labetolol (mean MAP increase not written)
- 0% 9%
Muench, 2007 [19] Triple-H or hypertension or hypervolemic hemodilution Prophylactic -norepinephrine to raise MAP above 130 mmHg (mean MAP increase not written)
-1,000 ml hydroxyethyl-starch and 1,000 to 3,000 ml crystalloids
- unknown unknown
  1. Ht, hematocrit; Int, Intervention