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Table 3 Temporal changes observed in 13 biguanide-intoxicated patients with central venous oxygen saturation (but not cardiac index) monitoring

From: Oxygen consumption is depressed in patients with lactic acidosis due to biguanide intoxication

  n Day 1 Day 2 Day 3 Day 4 P
pH 13 7.14 ± 0.17 7.36 ± 0.10* 7.45 ± 0.09* 7.43 ± 0.06* <0.001
Lactate (mM) 13 12 ± 6 5 ± 8* 2 ± 1* 2 ± 1* <0.001
C(a-v)O2
(ml O2/100 ml)
12 2.5 ± 1.1 3.1 ± 1.0 3.4 ± 0.8 4.2 ± 1.2* <0.05
SvO2 (%) 12 79 ± 10 75 ± 10 73 ± 6* 66 ± 7* 0.01
OEI (%) 12 20 ± 10 24 ± 10 25 ± 7 33 ± 7* 0.01
C(v-a)CO2
(ml CO2/100 ml)
8 2.4 ± 1.6 2.8 ± 1.2 3.6 ± 0.9 5.5 ± 1.9 0.16
RASS 13 -1 (-4-0) 0 (-3-0) 0 (-1-0) -1 (-3-0) 0.05
On MV (%) 13 31 42 27 38 0.89
HR 12 87 ± 17 88 ± 15 91 ± 14 88 ± 8 0.10
SOFA 13 9 ± 2 8 ± 3 6 ± 3* 7 ± 3* <0.001
Catecholamine use (SOFA sub score) 13 3 ± 2 3 ± 2 2 ± 2* 2 ± 2* <0.01
BT (°C) 10 35.8
(35.0-36.3)
36.8
(36.4-37.3)
37.0
(36.7-37.5)*
36.9
(36.6-37.4)
<0.05
  1. Results of repeated-measures analysis of variance and chi-squared test are reported in the right column. Data significantly different from day 1 on post-hoc comparison are indicated as *. n is the number of patients with each specific variable monitored on day 1.
  2. BT, body temperature; C(a-v)O2, arterio-venous difference in oxygen content; C(v-a)CO2, veno-arterial difference in carbon dioxide content; HR, heart rate; MV, mechanical ventilation; OEI, oxygen extraction index; RASS, Richmond Agitation Sedation Score; SOFA, Sequential Organ Failure Assessment; SvO2, central venous oxygen saturation.