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Table 2 Temporal changes observed in 11 biguanide-intoxicated patients with cardiac index and central venous oxygen saturation monitoring

From: Oxygen consumption is depressed in patients with lactic acidosis due to biguanide intoxication

 

n

Day 1

Day 2

Day 3

Day 4

P

pH

11

7.03

(6.92-7.15)

7.35

(7.25-7.40)

7.44

(7.35-7.46)*

7.46

(7.44-7.47)*

<0.001

Lactate (mM)

11

17 (14-20)

5 (2-15)

2 (2-3)*

1 (1-3)*

<0.001

VO2 (ml/min/m2)

9

67 ± 28

99 ± 30*

116 ± 41*

129 ± 42*

<0.001

DO2 (ml/min/m2)

9

443 ± 167

572 ± 152

491 ± 95

430 ± 116

<0.01

CI (L/min/m2)

9

3.4 ± 1.2

4.4 ± 1.3

3.9 ± 0.8

3.4 ± 1.2

0.08

C(a-v)O2

(ml O2/100 ml)

10

2.0 ± 1.0

2.4 ± 0.8

2.9 ± 0.8*

3.8 ± 1.4*

<0.001

SvO2 (%)

10

83 ± 8

80 ± 6

75 ± 5*

70 ± 8*

<0.001

OEI (%)

10

13 (11-19)

16 (13-21)

23 (21-25)*

31 (23-34)*

<0.001

C(v-a)CO2

(ml CO2/100 ml)

7

2.2 ± 0.8

2.2 ± 0.8

3.9 ± 1.9

4.7 ± 1.2*

<0.05

RASS

11

-4 (-5--2)

-4 (-4--1)

-2 (-4-0)

-1 (-3-0)

0.06

On MV (%)

11

91

100

67

67

0.12

HR

11

103 ± 20

104 ± 8

99 ± 16

97 ± 21

0.74

SOFA

11

12 ± 3

10 ± 1*

9 ± 2*

10 ± 2*

<0.001

Catecholamine use (SOFA sub score)

11

4 (4-4)

4 (4-4)

4 (4-4)

3 (2-3)*

<0.001

BT (°C)

10

34.5 ± 2.2

36.6 ± 0.6*

36.8 ± 0.4*

36.7 ± 0.5*

<0.001

  1. Results of repeated-measures analysis of variance and chi-squared test are reported in the right column. Data significantly different from day 1 on post-hoc comparison are indicated as *. n is the number of patients with each specific variable monitored on day 1.BT, body temperature; C(a-v)O2, arterio-venous difference in oxygen content; C(v-a)CO2, veno-arterial difference in carbon dioxide content; CI, cardiac index; DO2, systemic oxygen delivery; HR, heart rate; MV, mechanical ventilation; OEI, oxygen extraction index; RASS, Richmond Agitation Sedation Score; SOFA, Sequential Organ Failure Assessment; SvO2, central venous oxygen saturation; VO2, systemic oxygen consumption.