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Table 2 Temporal changes observed in 11 biguanide-intoxicated patients with cardiac index and central venous oxygen saturation monitoring

From: Oxygen consumption is depressed in patients with lactic acidosis due to biguanide intoxication

  n Day 1 Day 2 Day 3 Day 4 P
pH 11 7.03
(6.92-7.15)
7.35
(7.25-7.40)
7.44
(7.35-7.46)*
7.46
(7.44-7.47)*
<0.001
Lactate (mM) 11 17 (14-20) 5 (2-15) 2 (2-3)* 1 (1-3)* <0.001
VO2 (ml/min/m2) 9 67 ± 28 99 ± 30* 116 ± 41* 129 ± 42* <0.001
DO2 (ml/min/m2) 9 443 ± 167 572 ± 152 491 ± 95 430 ± 116 <0.01
CI (L/min/m2) 9 3.4 ± 1.2 4.4 ± 1.3 3.9 ± 0.8 3.4 ± 1.2 0.08
C(a-v)O2
(ml O2/100 ml)
10 2.0 ± 1.0 2.4 ± 0.8 2.9 ± 0.8* 3.8 ± 1.4* <0.001
SvO2 (%) 10 83 ± 8 80 ± 6 75 ± 5* 70 ± 8* <0.001
OEI (%) 10 13 (11-19) 16 (13-21) 23 (21-25)* 31 (23-34)* <0.001
C(v-a)CO2
(ml CO2/100 ml)
7 2.2 ± 0.8 2.2 ± 0.8 3.9 ± 1.9 4.7 ± 1.2* <0.05
RASS 11 -4 (-5--2) -4 (-4--1) -2 (-4-0) -1 (-3-0) 0.06
On MV (%) 11 91 100 67 67 0.12
HR 11 103 ± 20 104 ± 8 99 ± 16 97 ± 21 0.74
SOFA 11 12 ± 3 10 ± 1* 9 ± 2* 10 ± 2* <0.001
Catecholamine use (SOFA sub score) 11 4 (4-4) 4 (4-4) 4 (4-4) 3 (2-3)* <0.001
BT (°C) 10 34.5 ± 2.2 36.6 ± 0.6* 36.8 ± 0.4* 36.7 ± 0.5* <0.001
  1. Results of repeated-measures analysis of variance and chi-squared test are reported in the right column. Data significantly different from day 1 on post-hoc comparison are indicated as *. n is the number of patients with each specific variable monitored on day 1.BT, body temperature; C(a-v)O2, arterio-venous difference in oxygen content; C(v-a)CO2, veno-arterial difference in carbon dioxide content; CI, cardiac index; DO2, systemic oxygen delivery; HR, heart rate; MV, mechanical ventilation; OEI, oxygen extraction index; RASS, Richmond Agitation Sedation Score; SOFA, Sequential Organ Failure Assessment; SvO2, central venous oxygen saturation; VO2, systemic oxygen consumption.