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Figure 1 | Critical Care

Figure 1

From: Mild hypothermia alone or in combination with anesthetic post-conditioning reduces expression of inflammatory cytokines in the cerebral cortex of pigs after cardiopulmonary resuscitation

Figure 1

Experimental time line. Thirty pigs were subjected to cardiac arrest following left anterior descending (LAD) coronary artery ischemia. Ventricular fibrillation (VF) was electrically induced twenty minutes after LAD occlusion. After seven minutes of VF, pigs were resuscitated (CPR). After successful return of spontaneous circulation (ROSC; n = 21), coronary perfusion was reestablished after 60 minutes of LAD occlusion, and animals were randomized either to normothermia at 38°C, hypothermia at 33°C or hypothermia at 33°C combined with sevoflurane (each group n = 7) for 24 hours. Five animals were sham operated. In the normothermia group, five out of seven animals survived for 24 hours compared to all animals in the hypothermia and hypothermia combined with sevoflurane group.

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Critical Care

ISSN: 1364-8535