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Table 1 Markers of inflammation and large neutral amino acids

From: Cerebral net exchange of large neutral amino acids after lipopolysaccharide infusion in healthy humans

 

Baseline

LPS

Temperature (°C)

36.3 (36.0-36.6)

38.0 (37.6-38.6)‡‡

Total white blood cells (10 9 /L)

5.0 (4.5-5.5)

9.0 (8.0-10.2)‡‡

Neutrophils (10 9 /L)

2.7 (2.3-3.1)

7.6 (6.6-8.7)‡‡

Lymphocytes (10 9 /L)

1.5 (1.3-1.8)

0.8 (0.6-1.0)‡‡

TNF-α (ng/L)

0.9 (0.5-1.4)

10.4 (8.7-12.4)‡‡

BCAA/AAA ratio

5.2 (4.7-5.7)

4.9 (4.4-5.3)††

Phenylalanine (μmol/L)

36 (32-41)

41 (38-44)††

Tryptophan (μmol/L)

34 (31-38)

28 (25-32)††

Tyrosine (μmol/L)

41 (35-47)

34 (31-39)†

Valine (μmol/L)

224 (201-247)

200 (185-214)††

Leucine (μmol/L)

113 (101-26)

104 (95-112)†

Isoleucine (μmol/L)

59 (53-60)

57 (54-62)

Methionine (μmol/L)

14 (13-15)

9 (8-10)‡‡

Histidine (μmol/L)

74 (70-78)

58 (52-63)‡‡

Threonine (μmol/L)

102 (95-109)

74 (66-82)‡‡

Glutamine (μmol/L)

613 (556-669)

449 (411-486)‡‡

  1. AAA = aromatic amino acid; BCAA = branched-chain amino acid, LPS = lipopolysaccharide; TNF-α: tumor necrosis factor α. Different from baseline: †P < 0.05; ††P < 0.01; ‡‡P < 0.0001.