
Simple model

Multiple model


Variable

B

Pvalue

β

Pvalue


Sepsis (yes/no)

0.37

<0.0001

0.33

< 0.001

RIFLE category failure*

0.23

0.018

0.04

0.693

ln SOFA  total

0.16

0.098

0.03

0.738

ln SOFA  respiratory variable

0.17

0.075

0.13

0.140

ln SOFA  renal variable

0.22

0.020

0.23

0.007

ln CRP

0.40

<0.0001

0.21

0.031

ln cystatin C

0.34

<0.0001

0.26

0.005

 Multiple linear regression analysis using neutrophil gelatinaseassociated lipocalin as the dependent variable. Variables found to be statistical significant at a P value less than 0.1 in the simple model were included into the multiple linear regression analysis using stepwise backward elimination. Variables that were not normally distributed were log transformed. (β denotes standardized regression coefficient); A twosided P value of less than 0.05 was considered statistically significant in the multiple model. * β for categorical variables is only displayed in case of multivariate significance.
 CRP = C reactive protein; RIFLE = a newly developed international consensus classification for acute kidney injury, that defines three grades of severity  risk (class R), injury (class I) and failure (class F); SOFA = Sequential Organ Failure Assessment score.