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Table 1 Baseline characteristics at initiation of RRT

From: Serum neutrophil gelatinase-associated lipocalin at inception of renal replacement therapy predicts survival in critically ill patients with acute kidney injury

Variable Total non-SIRS/sepsis SIRS Sepsis Pvalue
Number of patients (n; %) 109 (100) 25 (22.9) 53 (48.6) 31 (28.4)  
Age (years, median (IQR)) 51 (40-61) 56 (47-68) 51 (39-60) 48 (37-61) 0.086
Female sex (n;%) 42 (38.5) 5 (20.0) 25 (47.2) 12 (38.7) 0.071
LOS before start of RRT (median (IQR)) 2 (1-5) 3 (2-5) 2 (1-7) 2 (1-5) 0.426
APACHE II score (median (IQR)) 34 (26-36) 34 (27-36) 30 (24-35) 35 (29-40) 0.028
SOFA score (median (IQR)) 16 (13-18) 15 (13-17) 14 (12-17) 17 (16-19) 0.011
   Cardiovascular variable 4 (1-4) 3 (1-4) 3 (1-4) 4 (3-4) 0.008
   Respiratory variable 2 (2-3) 2 (2-3) 2 (1-3) 3 (2-4) 0.005
   Coagulation variable 1 (1-3) 1 (1-3) 1 (1-3) 3 (1-3) 0.567
   Liver variable 1 (1-2) 1 (1-2) 2 (1-2) 1 (1-2) 0.858
   Renal variable 3 (2-4) 3 (2-4) 3 (2-4) 3 (2-4) 0.517
   CNS variable 4 (3-4) 4 (4-4) 4 (2-4) 4 (4-4) 0.009
Indication for RRT      
   CCR/eGFR loss >30% (n;%) 100 (91.7) 23 (92.0) 49 (92.5) 28 (90.3) 0.942
   Oliguria (n;%) 78 (71.6) 18 (72.0) 36 (37.9) 24 (77.4) 0.647
   Severe acidosis (n;%) 10 (9.2) 0 (0) 5 (9.4) 5 (16.5) 0.115
   Hyperkalemia (n;%) 6 (5.5) 0 (0) 3 (5.7) 3 (9.7) 0.287
RIFLE class      0.947
   Risk (n;%) 9 (8.3) 2 (8.0) 5 (9.4) 2 (6.5)  
   Injury (n;%) 13 (11.9) 2 (8.0) 7 (13.2) 4 (12.9)  
   Failure (n;%) 87 (79.8) 21 (84.0) 41 (77.4) 25 (80.6)  
Laboratory data (median (IQR))      
   CRP (mg/L) 138 (59-204) 113 (60-155) 67 (36-176) 202 (138-303 <0.001
   Creatinine (μmol/L) 236 (185-313) 277 (189-350) 250 (191-348) 203 (152-257) 0.475
   Cystatin C (mg/L) 1.82 (1.37-2.68) 1.81 (1.47-2.4) 1.82 (1.41-2.93) 1.84 (1.27-2.47) 0.676
   NGAL (ng/mL) 364 (196-582) 297 (184-490) 315 (161-455) 708 (365-1301) 0.001
  1. APACHE II score = Acute Physiology And Chronic Health Evaluation score; CCR = creatinine clearance; CNS = central nervous system; CRP = C reactive protein; eGFR = estimated glomerular filtration rate; IQR = interquartile range; LOS = length of stay in the intensive care unit; NGAL = neutrophil gelatinase-associated lipocalin; RIFLE = a newly developed international consensus classification for acute kidney injury, that defines three grades of severity - risk (class R), injury (class I) and failure (class F); RRT = renal replacement therapy; SOFA = Sequential Organ Failure Assessment score; SIRS = systemic inflammatory response syndrome.