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Figure 2 | Critical Care

Figure 2

From: Protective effect of resin adsorption on septic plasma-induced tubular injury

Figure 2

Protective effect of Amberchrom resin adsorption on septic plasma-induced TEC cytotoxicity. (a) Evaluation of cytotoxicity (XTT-based assay) after incubation of tubular epithelial cells (TEC) for 48 hours with increasing doses of septic plasma diluted in normal culture medium (RPMI 1640). Doses of 1% or more induced a significant decrease of TEC viability (*P < 0.05 Septic 1%, 2.5%, 5%, 10% and 20% vs Healthy plasma). (b) Time-course analysis of TEC cytotoxicity (XTT-based assay) induced by 5% septic plasma before and after Amberchrom resin adsorption. TEC treated with pre-adsorbed plasma showed a significant increase of hours at all time points considered (*P < 0.05 Septic + CG161 M vs. Septic at 12, 24 and 48 hours). Data are expressed as average O.D. intensity ± standard deviation. Analysis of variance with Newmann-Keuls multicomparison test was performed.

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