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Table 1 Biochemical and coagulation parameters before and after TPE

From: Therapeutic plasma exchange in children with acute liver failure: assessment of laboratory parameters

Variable

Before TPE

After TPE

Delta variable

P value

PT (sec)

40.9 (32.5 to 47.5)

21.1 (18.1 to 25.0)

17.8 (10.2 to 26.1)

0.0003

INR

3.6 (3.1 to 4.6)

1.7 (1.5 to 2.3)

1.7 (1.3 to 27.8)

0.0002

TB (mg/dl)

17.7 (11.7 to 21.5)

14.2 (9.6 to 18.0)

3.2 (1.1 to 6.0)

0.0006

DB (mg/dl)

10.3 (7.3 to 17.2)

7.9 (4.8 to 14.2)

1.9 (0.8 to 4.8)

0.0001

ALT (U/l)

122.5 (61.1 to 370)

87.5 (54 to 197.5)

38.1 (7 to 109.5)

0.0001

AST (U/l)

247.5 (122 to 399)

178 (85.5 to 272)

66.5 (14.1 to 223)

0.0002

Ammonia (mmol/l)

143.2 (81.5 to 195)

97.0 (71 to 150.5)

11.5 (3.5 to 59)

0.0003