Table 1
From: Metformin increases platelet lactate production by inhibiting mitochondrial function
No metformin | Metformin 0.01 mM | Metformin 1 mM | Metformin 100 mM | P value | |
|---|---|---|---|---|---|
Lactate (mM) | 5 ± 1 | 5 ± 1 | 10 ± 2 | 21 ± 4 | <0.001 |
FL2/FL1 | 5.6 ± 1.5 | 4.6 ± 1.1 | 4.6 ± 0.7 | 1.8 ± 0.7 | <0.001 |
Complex I (nM/minute/mg) | 6.8 ± 2.5 | 6.8 ± 2.3 | 4.0 ± 1.6 | 1.6 ± 1.4 | <0.001 |
CS (nM/minute/mg) | 102 ± 27 | 94 ± 15 | 99 ± 20 | 105 ± 10 | 0.74 |