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Regional lactate and oxygen saturation gradients: preliminary experimental data


Regional differences among blood flow and oxygen uptake are widely cited but not well explained. The lactate shuttle concept, alternative sets of lactate production, nowadays, challenges our comprehension about oxygen delivery and consumption. Recent studies have shown the prognostic value of oxygen and lactate gradients measured from central venous to pulmonary artery circulation. Our data represent one sample of our 4-year experimental research, trying to build a conceptual framework related to oxygen and lactate dynamic in different hypoxic states.


Sixteen large white pigs (35 kg) and seven shams were studied. After anesthesia and full monitorization (EKG, MAP, etCO2, continuous gas analysis, Doppler portal flow, small bowel tonometry, liver tpO2 and urine output), abdominal sepsis was induced by fecal peritonitis.


See Figures 1 and 2.

Figure 1
figure 1

Oxygen saturation gradients - heart and lung.

Figure 2
figure 2

Lactate gradients - heart and lung.


Our preliminary data show high rates of oxygen extraction rates in coronary circulation and suggest apparent lactate consumption by heart and lactate production by the lung, during experimental sepsis.

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Pereira, A., Rehder, P., Dias, C. et al. Regional lactate and oxygen saturation gradients: preliminary experimental data. Crit Care 14 (Suppl 1), P160 (2010).

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