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Table 3 Univariate and multivariate logistic regression analysis of risk factors associated with development of acute lung injury

From: Ventilation with lower tidal volumes as compared with conventional tidal volumes for patients without acute lung injury: a preventive randomized controlled trial

 

Lung injury

(n = 12)

No lung injury

(n = 138)

P value univariate analysis

P value multivariate analysis

Age (years)

63.5 (54.3-78.3)

63.0 (48.8-74.0)

0.41

-

Male gender (n, %)

9 (75%)

90 (65%)

0.49

-

APACHE-II score

19 (15-23)

20 (15-27)

0.82

-

LIS

1.5 (1.25-2.0)

1.25 (0.75-1.75)

0.03

-

ALI-risk factor (n, %)

10 (83%)

82 (59%)

0.10

0.14

Number of transfused blood products (median, IQR)

0 (0-13)

0 (0-2)

0.01

-

Oxygenation Index

5.2 (4.3-6.8)

3.9 (2.7-5.5)

0.04

-

PaO2/FiO2

34 (26-41)

(35 (28-45)

0.46

-

Conventional-tidal-volume group

10 (83%)

64 (46%)

0.01

0.007

PEEP level (cm H2O)

10 (8-12)

5 (5-9)

0.001

0.001

IL-6 level in lavage fluid (median with IQR, pg/ml)

592 (148-1,321)

226 (23-765)

0.04

-

IL-6 level in plasma (pg/ml)

79 (25-565)

48 (19-145)

0.13

-

TNF-α level in lavage fluid (median with IQR, pg/ml)

7.2 (1.0-121)

1.3 (0-30.6)

0.11

-

IL-1β level in lavage fluid (median with IQR, pg/ml)

9.0 (0.0-96.7)

42.4 (4.2-281)

0.32

-

  1. APACHE-II = acute physiology and chronic health evaluation-II; LIS = lung injury score. Data are expressed as medians with interquartile range or as number with percentage. Underlying risk factors in patients in whom lung injury developed were sepsis (n = 4), shock (n = 1), trauma (n = 1), drug overdose (n = 1), and multiple blood transfusions (n = 1) in the conventional-tidal-volume group, and pneumonia (n = 1) and shock (n = 1) in the lower-tidal-volume group.