Table 1 Demographic data

Age (years, mean ± SD)

58 (± 17)

63 (± 15)

0.06

Male sex (n, %)

50 (68%)

49 (64%)

0.69

Mechanical ventilation time before randomization (hours, mean ± SD)

20 (± 9)

18 (± 9)

0.25

Tidal volume before randomization (ml/kg ideal body weight, mean ± SD)

8.2 (± 0.4)

8.4 (± 0.6)

0.31

APACHE II score (mean ± SD)

20 (± 8)

21 (± 7)

0.93

SOFA score (mean ± SD)

8 (± 4)

7 (± 3)

0.19

LIS (mean ± SD)

1.2 (± 0.6)

1.3 (± 0.6)

0.08

P/F (mean ± SD)

40.0 (± 8.9)

36.0 (± 11.4)

0.14

ALI/ARDS consensus criteria

0.91

   PF >40 and normal CXR

17

17

   PF >40 and abnormal CXR

6

6

   PF <40 and normal CXR

33

34

   PF <40 and unilateral CXR abnormality

18

19

   PF <40 and bilateral abnormality with heart failure

0

1

Underlying ALI risk factors

0.60

   Sepsis

7

4

   Shock

6

9

   Pneumonia

1

3

   Glasgow Coma Scale ≤ 8

19

13

   Trauma

12

10

   Other

2

2

Blood transfusion

30 (41%)

36 (47%)

0.40

   Any blood products (median, IQR)

0 (0-15)

0 (0-4)

0.52

   Packed red cells (median, IQR)

0 (0-2)

0 (0-0)

0.25

   Filtered red cells (median, IQR)

0 (0-2)

0 (0-1)

0.08

   Platelets (median, IQR)

0 (0-0)

0 (0-0)

0.13

   Fresh frozen plasma (median, IQR)

0 (0-3)

0 (0-2)

0.08

Chronic alcohol abuse

6 (8%)

5 (7%)

0.72

Current smokers

45 (61%)

58 (76%)

0.04