Figure 1From: Combination effect of antithrombin and recombinant human soluble thrombomodulin in a lipopolysaccharide induced rat sepsis modelComparison of fibrinogen levels. The plasma fibrinogen level decreased significantly decreased at eight hours after lipopolysaccharide (LPS) injection, and this decrease was suppressed by treatment with either antithrombin (AT) or thrombomodulin (TM) in a dose-dependent manner (n = 6, for each dose). The fibrinogen levels were 126.6 ± 11.1 mg/dL and 124.2 ± 14.7 mg/dL after pre-treatment with 125 IU/kg of AT and 0.25 mg/kg of TM, respectively. N = normal; C = control.Back to article page