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Table 1 Patient characteristics

From: Hemostasis during low molecular weight heparin anticoagulation for continuous venovenous hemofiltration: a randomized cross-over trial comparing two hemofiltration rates

 

Group 1

4 L to 2 L/h

 

Group 2

2 L to 4 L/h

  
 

n = 7

 

N = 7

  

Age (years)

65

(38-69)

65

(60-75)

 

Male/female (n)

5/2

 

5/2

  

Body weight (kg)

75

(72-80)

75

(60-98)

 

Cause of ARF (n)

     

   sepsis

5

 

5

  

   cardiogenic shock

2

 

1

  

   liver failure

  

1

  

APACHE II

35

(29-38)

25

(19-31) 0.07

 

APACHE II predicted mortality (%)

85

(72-88)

56

(21-73) 0.10

 

APACHE III

128

(104-138)

94

(50-148)

0.18

SOFA start CVVH

14

(11-15)

9

(5-9)

0.004

Hemoglobin (mmol/L)

5.7

(4.8-6.5)

5.8

(5.6-6.1)

 

Hematocrit

0.29

(0.25-0.30)

0.28

(0.26-0.30)

 

PTT (sec)

11.8

(10.8-14.5)

11.4

(11.1-12.7)

0.95

aPTT (sec)

32.3

(25.5-36.7)

28.2

(20.3-41.7)

0.57

Antithrombin (%)

79

(43-86)

46

(17-64)

0.23

Platelet count (109/L)

182

(163-286)

139

(96-221)

0.26

Anti-Xa activity (IU)

0.11

(0.00-0.55)

0.01

(0.00-0.15)

0.30

ETPTlag (sec)

23.0

(18.6-31.0)

19.7

(14.3-22.1)

0.13

ETPTmax (sec)

53.1

(46.0-81.4)

52.7

(46.1-54.9)

0.80

ETPCmax (mA/min)

108

(91-125)

114

(75-153)

0.48

ETPAUC (mA)

275

(137-379)

341

(223-401)

0.54

F1+2 (pmol/L)

313

(158-689)

216

(156-288)

0.32

TAT (μg/L)

20.7

(4.8-28.9)

8.3

(6.7-10.5)

0.18

D-dimers (μg/ml)

14.2

(7.6-43.8)

4.1

(1.5-29.8)

0.25

Creatinine (μmol/L)

297

(221-453)

251

(141-329)

0.54

Urea (mmol/L)

34

(15-49)

36

(10-47)

0.81

RIFLE score

3

 

3

 

1.0

  1. Values in median (interquartile range) unless indicated differently.
  2. APACHE = Acute Physiology and Chronic Health Evaluation; aPTT = activated thromboplastin time; CVVH = continuous venovenous hemofiltration; ETP = endogenous thrombin potential; ETPAUC = area under the curve of the thrombin generation curve; ETPCmax = maximal activity of ETP; ETPTlag = ETP lag time = ETPTmax = time to max ETP activity; F1+2 = prothrombin fragment; PTT = prothrombin time; SOFA = Sequential Organ Failure Assessment; TAT = thrombin-antithrombin complexes.
  3. RIFLE = Risk = 1, Injury = 2, Failure = 3.