Variables | Treatment | Pre-sepsis | 0 h | 2 h | 4 h | 6 h |
---|---|---|---|---|---|---|
Ph | Ang II | 7.489 ± 0.025 | 7.518 ± 0.036 | 7.509 ± 0.049 | 7.518 ± 0.055 | 7.517 ± 0.060 |
 | Vehicle | 7.449 ± 0.075 | 7.496 ± 0.054 | 7.520 ± 0.055 | 7.506 ± 0.049 | 7.496 ± 0.042 |
PaCO 2 (Torr (kPa)) | Ang II | 34.9 ± 1.9 (4.65 ± 0.25) | 31.0 ± 3.4* (4.13 ± 0.45) | 34.5 ± 4.0 (4.60 ± 0.53) | 35.2 ± 3.8 (4.69 ± 0.51) | 36.0 ± 3.6 (4.80 ± 0.48) |
 | Vehicle | 33.8 ± 2.3 (4.37 ± 0.31) | 31.6 ± 2.3* (4.21 ± 0.31) | 36.0 ± 6.3 (4.80 ± 0.84) | 36.0 ± 6.8 (4.80 ± 0.91) | 37.3 ± 10.3 (4.97 ± 1.37) |
Pa O 2 (Torr (kPa)) | Ang II | 97.5 ± 12.0 (13.0 ± 1.6) | 85.5 ± 3.5* (11.4 ± 0.5) | 89.0 ± 6.8 (11.9 ± 0.9) | 87.6 ± 10.3 (11.7 ± 1.4) | 84.9 ± 10.0 (11.3 ± 1.3) |
 | Vehicle | 97.8 ± 5.1 (13.0 ± 0.7) | 92.3 ± 10.2* (12.4 ± 1.4) | 83.4 ± 10.4 (11.1 ± 1.4) | 89.3 ± 7.9 (11.9 ± 1.1) | 83.1 ± 9.1 (11.1 ± 1.2) |
HCO 3 - (mmol/l) | Ang II | 26.3 ± 1.6 | 24.9 ± 1.5 | 27.2 ± 2.4 | 28.4 ± 2.9 | 29.0 ± 2.8 |
 | Vehicle | 23.3 ± 3.7 | 24.3 ± 2.3 | 29.2 ± 5.1 | 28.4 ± 6.9 | 28.7 ± 8.8 |
BE (mmol/l) | Ang II | 3.4 ± 1.6 | 2.7 ± 1.4 | 4.4 ± 2.6 | 5.5 ± 3.0 | 5.9 ± 3.1 |
 | Vehicle | 0.0 ± 4.6 | 1.6 ± 2.7 | 6.2 ± 4.7 | 5.2 ± 6.1 | 5.3 ± 7.5 |
K + (mmol/l) | Ang II | 4.3 ± 0.2 | 4.1 ± 0.4 | 4.1 ± 0.6 | 4.0 ± 0.7 | 3.9 ± 0.7 |
 | Vehicle | 4.0 ± 0.4 | 3.9 ± 0.3 | 4.1 ± 0.3 | 4.3 ± 0.4 | 4.2 ± 0.4 |
Na + (mmol/l) | Ang II | 142.3 ± 3.8 | 143.3 ± 3.2 | 143.2 ± 2.5 | 142.0 ± 2.5 | 141.3 ± 2.4 |
 | Vehicle | 143.2 ± 1.9 | 143.8 ± 3.4 | 144.0 ± 4.0 | 144.0 ± 4.6 | 144.0 ± 4.6 |
Ca 2+ (mmol/l) | Ang II | 1.2 ± 0.1 | 1.1 ± 0.1* | 1.1 ± 0.1 | 1.0 ± 0.1 | 1.0 ± 0.2 |
 | Vehicle | 1.2 ± 0.1 | 1.1 ± 0.1* | 1.1 ± 0.1 | 1.1 ± 0.0 | 1.2 ± 0.0 |
Cl - (mmol/l) | Ang II | 109.7 ± 3.3 | 111.5 ± 5.9 | 106.8 ± 3.4 | 105.0 ± 3.7 | 103.3 ± 4.1 |
 | Vehicle | 108.8 ± 2.1 | 108.0 ± 3.2 | 108.0 ± 3.6 | 107.8 ± 4.3 | 108.5 ± 4.2 |
Lactate (mmol/l) | Ang II | 0.6 ± 0.2 | 2.1 ± 1.4* | 2.1 ± 1.6 | 1.8 ± 1.2 | 1.7 ± 1.4 |
 | Vehicle | 0.5 ± 0.1 | 1.9 ± 1.2* | 1.8 ± 1.3 | 1.5 ± 1.3 | 1.4 ± 1.4 |
HB (g/dl) | Ang II | 9.9 ± 1.2 | 10.8 ± 1.0 | 10.1 ± 1.3 | 9.8 ± 0.9 | 9.9 ± 1.1 |
 | Vehicle | 9.7 ± 1.6 | 10.2 ± 1.1 | 9.9 ± 1.1 | 9.6 ± 1.1 | 9.6 ± 1.0 |