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Table 1 Blood and plasma levels of biochemical variables during the pre-sepsis period, immediately before treatment, and then at 2, 4 and 6 hours of Ang II or vehicle infusion (n = 6 in both groups)

From: Angiotensin II in experimental hyperdynamic sepsis

Variables

Treatment

Pre-sepsis

0 h

2 h

4 h

6 h

Ph

Ang II

7.489 ± 0.025

7.518 ± 0.036

7.509 ± 0.049

7.518 ± 0.055

7.517 ± 0.060

 

Vehicle

7.449 ± 0.075

7.496 ± 0.054

7.520 ± 0.055

7.506 ± 0.049

7.496 ± 0.042

PaCO 2 (Torr (kPa))

Ang II

34.9 ± 1.9

(4.65 ± 0.25)

31.0 ± 3.4*

(4.13 ± 0.45)

34.5 ± 4.0

(4.60 ± 0.53)

35.2 ± 3.8

(4.69 ± 0.51)

36.0 ± 3.6

(4.80 ± 0.48)

 

Vehicle

33.8 ± 2.3

(4.37 ± 0.31)

31.6 ± 2.3*

(4.21 ± 0.31)

36.0 ± 6.3

(4.80 ± 0.84)

36.0 ± 6.8

(4.80 ± 0.91)

37.3 ± 10.3

(4.97 ± 1.37)

Pa O 2 (Torr (kPa))

Ang II

97.5 ± 12.0

(13.0 ± 1.6)

85.5 ± 3.5*

(11.4 ± 0.5)

89.0 ± 6.8

(11.9 ± 0.9)

87.6 ± 10.3

(11.7 ± 1.4)

84.9 ± 10.0

(11.3 ± 1.3)

 

Vehicle

97.8 ± 5.1

(13.0 ± 0.7)

92.3 ± 10.2*

(12.4 ± 1.4)

83.4 ± 10.4

(11.1 ± 1.4)

89.3 ± 7.9

(11.9 ± 1.1)

83.1 ± 9.1

(11.1 ± 1.2)

HCO 3 - (mmol/l)

Ang II

26.3 ± 1.6

24.9 ± 1.5

27.2 ± 2.4

28.4 ± 2.9

29.0 ± 2.8

 

Vehicle

23.3 ± 3.7

24.3 ± 2.3

29.2 ± 5.1

28.4 ± 6.9

28.7 ± 8.8

BE (mmol/l)

Ang II

3.4 ± 1.6

2.7 ± 1.4

4.4 ± 2.6

5.5 ± 3.0

5.9 ± 3.1

 

Vehicle

0.0 ± 4.6

1.6 ± 2.7

6.2 ± 4.7

5.2 ± 6.1

5.3 ± 7.5

K + (mmol/l)

Ang II

4.3 ± 0.2

4.1 ± 0.4

4.1 ± 0.6

4.0 ± 0.7

3.9 ± 0.7

 

Vehicle

4.0 ± 0.4

3.9 ± 0.3

4.1 ± 0.3

4.3 ± 0.4

4.2 ± 0.4

Na + (mmol/l)

Ang II

142.3 ± 3.8

143.3 ± 3.2

143.2 ± 2.5

142.0 ± 2.5

141.3 ± 2.4

 

Vehicle

143.2 ± 1.9

143.8 ± 3.4

144.0 ± 4.0

144.0 ± 4.6

144.0 ± 4.6

Ca 2+ (mmol/l)

Ang II

1.2 ± 0.1

1.1 ± 0.1*

1.1 ± 0.1

1.0 ± 0.1

1.0 ± 0.2

 

Vehicle

1.2 ± 0.1

1.1 ± 0.1*

1.1 ± 0.1

1.1 ± 0.0

1.2 ± 0.0

Cl - (mmol/l)

Ang II

109.7 ± 3.3

111.5 ± 5.9

106.8 ± 3.4

105.0 ± 3.7

103.3 ± 4.1

 

Vehicle

108.8 ± 2.1

108.0 ± 3.2

108.0 ± 3.6

107.8 ± 4.3

108.5 ± 4.2

Lactate (mmol/l)

Ang II

0.6 ± 0.2

2.1 ± 1.4*

2.1 ± 1.6

1.8 ± 1.2

1.7 ± 1.4

 

Vehicle

0.5 ± 0.1

1.9 ± 1.2*

1.8 ± 1.3

1.5 ± 1.3

1.4 ± 1.4

HB (g/dl)

Ang II

9.9 ± 1.2

10.8 ± 1.0

10.1 ± 1.3

9.8 ± 0.9

9.9 ± 1.1

 

Vehicle

9.7 ± 1.6

10.2 ± 1.1

9.9 ± 1.1

9.6 ± 1.1

9.6 ± 1.0

  1. Results are mean ± standard deviation. There were no significant differences between the Ang II and vehicle groups. * statistical difference between pre-sepsis period and sepsis control period. Ang II = angiotensin II; BE = base excess; HB = hemoglobin; PaCO2 = partial pressure of arterial carbon dioxide; PaO2 = partial pressure of arterial oxygen.