Table 1 Systemic hemodynamics
From: Effect of fluid resuscitation on mortality and organ function in experimental sepsis models
Variable | Group | N | Intra-operative | Baseline | 3 hours | 6 hours | 12 hours | End | Interactions | P |
|---|---|---|---|---|---|---|---|---|---|---|
Cardiac index (ml/kg/min) |  |  |  |  |  |  |  |  | Time × model effect: | 0.02 |
|  | C 10 ml/kg | 8 | n. a. | 89 ± 14 | 88 ± 21 | 93 ± 22 | 100 ± 32 | 103 ± 24 |  |  |
|  | C 20 ml/kg | 8 | n. a. | 73 ± 24 | 88 ± 10 | 92 ± 11 | 96 ± 22 | 99 ± 14 |  |  |
|  | E 10 ml/kg | 7 | n. a. | 75 ± 17 | 69 ± 21 | 84 ± 25 | 98 ± 29 | 113 ± 32 |  |  |
|  | E 20 ml/kg | 8 | n. a. | 87 ± 19 | 83 ± 24 | 106 ± 33 | 130 ± 37 | 117 ± 38 | ANOVArm E: | 0.002 |
|  | P 10 ml/kg | 8 | n. a. | 86 ± 17 | 92 ± 28 | 105 ± 26 | 87 ± 26 | 94 ± 13 |  |  |
|  | P 20 ml/kg | 8 | n. a. | 82 ± 12 | 113 ± 31 | 103 ± 21 | 108 ± 24 | 133 ± 73 | ANOVArm P: | 0.04 |
Heart rate (beats/min) |  |  |  |  |  |  |  |  | Time × model effect: | 0.001 |
|  | C 10 ml/kg | 8 | 116 ± 19 | 114 ± 38* | 129 ± 40 | 138 ± 45 | 147 ± 42 | 138 ± 27 | ANOVArm C: | 0.04 |
|  | C 20 ml/kg | 8 | 126 ± 24 | 112 ± 25* | 107 ± 18 | 124 ± 33 | 125 ± 29 | 135 ± 37 |  |  |
|  | E 10 ml/kg | 7 | 119 ± 20 | 99 ± 12* | 114 ± 28 | 130 ± 28 | 153 ± 27 | 166 ± 20 | ANOVArm E: | 0.002 |
|  | E 20 ml/kg | 8 | 122 ± 16 | 111 ± 22* | 99 ± 15 | 117 ± 25 | 137 ± 36 | 136 ± 33 |  |  |
|  | P 10 ml/kg | 8 | 115 ± 19 | 114 ± 12* | 164 ± 24 | 186 ± 27 | 165 ± 37 | 148 ± 36 | ANOVArm P: | 0.001 |
|  | P 20 ml/kg | 8 | 117 ± 13 | 99 ± 11* | 158 ± 37 | 175 ± 20 | 154 ± 35 | 156 ± 47 |  |  |
Stroke volume index (ml/kg/beat) |  |  |  |  |  |  |  |  | Time × volume effect: | 0.03 |
|  | C 10 ml/kg | 8 | n. a. | 0.8 ± 0.2 | 0.7 ± 0.3 | 0.7 ± 0.3 | 0.7 ± 0.2 | 0.8 ± 0.3 | ANOVArm moderate-volume: | 0.018 |
|  | C 20 ml/kg | 8 | n. a. | 0.7 ± 0.3 | 0.8 ± 0.1 | 0.8 ± 0.2 | 0.8 ± 0.2 | 0.8 ± 0.2 |  |  |
|  | E 10 ml/kg | 7 | n. a. | 0.8 ± 0.1 | 0.6 ± 0.2 | 0.7 ± 0.2 | 0.7 ± 0.3 | 0.7 ± 0.2 |  |  |
|  | E 20 ml/kg | 8 | n. a. | 0.8 ± 0.2 | 0.9 ± 0.3 | 0.9 ± 0.3 | 1.0 ± 0.4 | 1.0 ± 0.5 |  |  |
|  | P 10 ml/kg | 8 | n. a. | 0.8 ± 0.1 | 0.6 ± 0.2 | 0.6 ± 0.1 | 0.6 ± 0.3 | 0.7 ± 0.2 |  |  |
|  | P 20 ml/kg | 8 | n. a. | 0.8 ± 0.1 | 0.8 ± 0.3 | 0.6 ± 0.2 | 0.7 ± 0.2 | 0.9 ± 0.5 |  |  |
Mean arterial pressure (mmHg) |  |  |  |  |  |  |  |  | Time × model effect: Time × volume effect: | 0.001 0.03 |
|  | C 10 ml/kg | 8 | 91 ± 13 | 71 ± 7# | 69 ± 14 | 72 ± 12 | 75 ± 5 | 72 ± 14 |  |  |
|  | C 20 ml/kg | 8 | 92 ± 5 | 69 ± 11# | 75 ± 15 | 77 ± 15 | 83 ± 15 | 76 ± 24 | ANOVArm high-volume: | 0.001 |
|  | E 10 ml/kg | 7 | 97 ± 8 | 69 ± 8# | 86 ± 12 | 76 ± 14 | 78 ± 11 | 80 ± 11 |  |  |
|  | E 20 ml/kg | 8 | 99 ± 19 | 70 ± 13# | 105 ± 8 | 102 ± 16 | 86 ± 18 | 74 ± 23 | ANOVArm E: | 0.001 |
|  | P 10 ml/kg | 8 | 87 ± 13 | 69 ± 10# | 75 ± 14 | 64 ± 10 | 66 ± 15 | 49 ± 20 |  |  |
|  | P 20 ml/kg | 8 | 86 ± 16 | 74 ± 26# | 86 ± 23 | 83 ± 23 | 76 ± 27 | 61 ± 25 | ANOVArm P: | 0.002 |
Mean pulmonary artery pressure (mmHg) |  |  |  |  |  |  |  |  | Time × model effect: Time × volume effect: | 0.003 0.01 |
|  | C 10 ml/kg | 8 | n. a. | 17 ± 4 | 19 ± 6 | 18 ± 3 | 20 ± 4 | 25 ± 3 | ANOVArm moderate-volume: | 0.001 |
|  | C 20 ml/kg | 8 | n. a. | 18 ± 4 | 20 ± 5 | 19 ± 5 | 23 ± 7 | 29 ± 6 | ANOVArm C: | 0.001 |
|  | E 10 ml/kg | 7 | n. a. | 17 ± 2 | 27 ± 7 | 25 ± 6 | 22 ± 5 | 26 ± 5 | ANOVArm E: | 0.001 |
|  | E 20 ml/kg | 7 | n. a. | 17 ± 3 | 33 ± 12 | 27 ± 6 | 29 ± 13 | 34 ± 11 |  |  |
|  | P 10 ml/kg | 8 | n. a. | 16 ± 3 | 23 ± 6 | 20 ± 3 | 21 ± 4 | 24 ± 3 | ANOVArm P: | 0.001 |
|  | P 20 ml/kg | 7 | n. a. | 18 ± 3 | 25 ± 5 | 25 ± 4 | 29 ± 6 | 36 ± 6 | ANOVArm high-volume: | 0.001 |