TY - JOUR AU - Weber, P. AU - Wang, P. AU - Maddens, S. AU - Wang, P. S. H. AU - Wu, R. AU - Miksa, M. AU - Dong, W. AU - Mortimore, M. AU - Golec, J. M. C. AU - Charlton, P. PY - 2009 DA - 2009// TI - VX-166: a novel potent small molecule caspase inhibitor as a potential therapy for sepsis JO - Crit Care VL - 13 UR - https://doi.org/10.1186/cc8041 DO - 10.1186/cc8041 ID - Weber2009 ER - TY - JOUR AU - Angus, D. C. AU - Linde-Zwirble, W. T. AU - Lidicker, J. AU - Clermont, G. AU - Carcillo, J. AU - Pinsky, M. R. PY - 2001 DA - 2001// TI - Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care JO - Crit Care Med VL - 29 UR - https://doi.org/10.1097/00003246-200107000-00002 DO - 10.1097/00003246-200107000-00002 ID - Angus2001 ER - TY - JOUR AU - Dombrovskiy, V. Y. AU - Martin, A. A. AU - Sunderram, J. AU - Paz, H. L. PY - 2007 DA - 2007// TI - Rapid increase in hospitalization and mortality rates for severe sepsis in the United States: a trend analysis from 1993 to 2003 JO - Crit Care Med VL - 35 UR - https://doi.org/10.1097/01.CCM.0000261890.41311.E9 DO - 10.1097/01.CCM.0000261890.41311.E9 ID - Dombrovskiy2007 ER - TY - JOUR AU - Martin, G. S. AU - Mannino, D. M. AU - Eaton, S. AU - Moss, M. PY - 2003 DA - 2003// TI - The epidemiology of sepsis in the United States from 1979 through 2000 JO - N Engl J Med VL - 348 UR - https://doi.org/10.1056/NEJMoa022139 DO - 10.1056/NEJMoa022139 ID - Martin2003 ER - TY - JOUR AU - Murch, O. AU - Collin, M. AU - Hinds, C. J. AU - Thiemermann, C. PY - 2007 DA - 2007// TI - Lipoproteins in inflammation and sepsis. I. Basic science JO - Intensive Care Med VL - 33 UR - https://doi.org/10.1007/s00134-006-0432-y DO - 10.1007/s00134-006-0432-y ID - Murch2007 ER - TY - JOUR AU - Watson, R. S. AU - Carcillo, J. A. AU - Linde-Zwirble, W. T. AU - Clermont, G. AU - Lidicker, J. AU - Angus, D. C. PY - 2003 DA - 2003// TI - The epidemiology of severe sepsis in children in the United States JO - Am J Respir Crit Care Med VL - 167 UR - https://doi.org/10.1164/rccm.200207-682OC DO - 10.1164/rccm.200207-682OC ID - Watson2003 ER - TY - JOUR AU - Wheeler, D. S. AU - Zingarelli, B. AU - Wheeler, W. J. AU - Wong, H. R. PY - 2009 DA - 2009// TI - Novel pharmacologic approaches to the management of sepsis: targeting the host inflammatory response JO - Recent Pat Inflamm Allergy Drug Discov VL - 3 UR - https://doi.org/10.2174/187221309788489779 DO - 10.2174/187221309788489779 ID - Wheeler2009 ER - TY - JOUR AU - Rivers, E. AU - Nguyen, B. AU - Havstad, S. AU - Ressler, J. AU - Muzzin, A. AU - Knoblich, B. AU - Peterson, E. AU - Tomlanovich, M. PY - 2001 DA - 2001// TI - Early goal-directed therapy in the treatment of severe sepsis and septic shock JO - N Engl J Med VL - 345 UR - https://doi.org/10.1056/NEJMoa010307 DO - 10.1056/NEJMoa010307 ID - Rivers2001 ER - TY - JOUR AU - Bernard, G. AU - Vincent, J. L. AU - Laterre, P. F. AU - LaRosa, S. P. AU - Dhainaut, J. F. AU - Lopez-Rodriguez, A. AU - Steingrub, J. S. AU - Garber, G. E. AU - Helterbrand, J. D. AU - Ely, E. W. AU - Fisher, C. J. PY - 2001 DA - 2001// TI - Efficacy and safety of recombinant human activated protein C for severe sepsis JO - N Engl J Med VL - 344 UR - https://doi.org/10.1056/NEJM200103083441001 DO - 10.1056/NEJM200103083441001 ID - Bernard2001 ER - TY - JOUR AU - Annane, D. AU - Sebille, V. AU - Charpentier, C. AU - Bollaert, P. E. AU - Francois, B. AU - Korach, J. M. AU - Capellier, G. AU - Cohen, Y. AU - Azoulay, E. AU - Troche, G. AU - Chaumet-Riffaud, P. AU - Bellisant, E. PY - 2002 DA - 2002// TI - Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock JO - JAMA VL - 288 UR - https://doi.org/10.1001/jama.288.7.862 DO - 10.1001/jama.288.7.862 ID - Annane2002 ER - TY - JOUR AU - Sprung, C. L. AU - Annane, D. AU - Keh, D. AU - Moreno, R. AU - Singer, M. AU - Freivogel, K. AU - Weiss, Y. G. AU - Benbenishty, J. AU - Kalenka, A. AU - Forst, H. AU - Laterre, P. F. AU - Reinhart, K. AU - Cuthbertson, B. H. AU - Payen, D. AU - Briegel, J. PY - 2008 DA - 2008// TI - Hydrocortisone therapy for patients with septic shock JO - N Engl J Med VL - 358 UR - https://doi.org/10.1056/NEJMoa071366 DO - 10.1056/NEJMoa071366 ID - Sprung2008 ER - TY - JOUR AU - Laupland, K. B. AU - Kirkpatrick, A. W. AU - Delaney, A. PY - 2007 DA - 2007// TI - Polyclonal intravenous immunoglobulin for the treatment of severe sepsis and septic shock in critically ill adults: a systematic review and meta-analysis JO - Crit Care Med VL - 35 UR - https://doi.org/10.1097/01.CCM.0000295312.13466.1C DO - 10.1097/01.CCM.0000295312.13466.1C ID - Laupland2007 ER - TY - JOUR AU - Wesche-Soldato, D. E. AU - Swan, R. Z. AU - Chung, C. S. AU - Ayala, A. PY - 2007 DA - 2007// TI - The apoptotic pathway as a therapeutic target in sepsis JO - Curr Drug Targets VL - 8 UR - https://doi.org/10.2174/138945007780362764 DO - 10.2174/138945007780362764 ID - Wesche-Soldato2007 ER - TY - JOUR AU - Kerr, J. F. AU - Wyllie, A. H. AU - Currie, A. R. PY - 1972 DA - 1972// TI - Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics JO - Br J Cancer VL - 26 UR - https://doi.org/10.1038/bjc.1972.33 DO - 10.1038/bjc.1972.33 ID - Kerr1972 ER - TY - JOUR AU - Jin, Z. AU - El-Deiry, W. S. PY - 2005 DA - 2005// TI - Overview of cell death signaling pathways JO - Cancer Biol Ther VL - 4 UR - https://doi.org/10.4161/cbt.4.2.1508 DO - 10.4161/cbt.4.2.1508 ID - Jin2005 ER - TY - JOUR AU - Hotchkiss, R. S. AU - Nicholson, D. W. PY - 2006 DA - 2006// TI - Apoptosis and caspases regulate death and inflammation in sepsis JO - Nat Rev Immunol VL - 6 UR - https://doi.org/10.1038/nri1943 DO - 10.1038/nri1943 ID - Hotchkiss2006 ER - TY - JOUR AU - Tang, P. S. AU - Mura, M. AU - Seth, R. AU - Liu, M. PY - 2008 DA - 2008// TI - Acute lung injury and cell death: how many ways can cells die? JO - Am J Physiol Lung Cell Mol Physiol VL - 294 UR - https://doi.org/10.1152/ajplung.00262.2007 DO - 10.1152/ajplung.00262.2007 ID - Tang2008 ER - TY - JOUR AU - Hotchkiss, R. S. AU - Coopersmith, C. M. AU - Karl, I. E. PY - 2005 DA - 2005// TI - Prevention of lymphocyte apoptosis - a potential treatment of sepsis? JO - Clin Infect Dis VL - 41 UR - https://doi.org/10.1086/431998 DO - 10.1086/431998 ID - Hotchkiss2005 ER -