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Figure 3 | Critical Care

Figure 3

From: Early release of high mobility group box nuclear protein 1 after severe trauma in humans: role of injury severity and tissue hypoperfusion

Figure 3

High plasma levels of HMGB1 are associated with coagulation abnormalities in trauma patients. Blood samples were obtained from 168 consecutive major trauma patients immediately upon admission to the hospital. (a) Trauma patients with coagulation abnormalities (international normalized ratio (INR) >1.5) had significantly higher levels of high mobility group box nuclear protein 1 (HMGB1). *P ≤ 0.05 from patients with INR <1.5. (b to d) High plasma levels of HMGB1 were associated with coagulation derangements early after trauma that are not due to coagulation factor deficiency as shown by the rise in the levels of soluble PF 1+2, a marker of thrombin generation and soluble thrombomodulin as well as a fall in protein C levels. Data are presented in quartiles, *P ≤ 0.05 based on test for rank and trend.

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Critical Care

ISSN: 1364-8535