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Table 2 Comparison of patients with and without ARDS during neutropenia recovery

From: Risk factors for acute respiratory distress syndrome during neutropenia recovery in patients with hematologic malignancies

 

ARDS during NR

No ARDS during NR

Odd ratio

95% CI

P value

Age

45.99 ± 1.79

45.38 ± 2.51

  

0.84

Male

20 (52.6%)

13 (39.4%)

1.71

0.66-4.40

0.27

AML

17 (44.7%)

18 (54.5%)

0.68

0.26-1.72

0.41

   ALL

12 (31.6%)

10 (30.3%)

1.06

0.39-2.91

0.91

   Relapsed maligancy

10 (26.3%)

7 (21.2%)

1.33

0.44-3.99

0.62

   Time from diagnosis, days

244 ± 98.7

140 ± 56.8

  

0.38

   Anthracycline treatment

20 (52.6%)

18 (54.5%)

0.93

0.36-2.36

0.87

   Cyclophosphamide treatment

9 (23.7%)

5 (15.2%)

1.74

0.52-5.83

0.37

   Methotrexate treatment

6 (15.8%)

3 (9.1%)

1.88

0.43-8.12

0.49

   Total chemotherapy times

2.79 ± 0.27

2.36 ± 0.25

  

0.26

   Total chemotherapy times ≥3 times

20 (52.6%)

14 (42.4%)

1.51

0.59-3.86

0.39

   Previous history of HSCT

8 (21.1%)

5 (15.2%)

1.88

0.43-8.18

0.52

   Time between chemotherapy and onset of neutropenia

3.45 ± 0.69

2.18 ± 0.65

  

0.19

   Time between chemotherapy and onset of neutropenia >10 days

3 (7.9%)

1 (3.0%)

2.74

0.27-27.73

0.62

   Neutropenia duration, days

22.4 ± 2.3

22.7 ± 2.4

  

0.94

   Neutropenia duration >10 days

34 (89.5%)

26 (78.8%)

2.29

0.61-8.66

0.22

   Platelet transfusion during neutropenia

38 (100%)

32 (97%)

  

0.47

   Plasma transfusion during neutropenia

33 (86.8%)

26 (78.8%)

1.78

0.51-6.25

0.37

   Pneumonia during neutropenia

32 (84.2%)

13 (39.4%)

8.21

2.68-25.07

< 0.001

   RRT during neutropenia

13 (34.2%)

8 (24.2%)

1.63

0.57-4.60

0.36

   ICU admission for respiratory failure

25 (65.8%)

10 (30.3%)

4.42

1.63-12.03

0.003

   Mechanical ventilator therapy

34 (89.5%)

19 (57.6%)

6.26

1.80-21.75

0.002

   In-ICU mortality

33 (86.8%)

17 (51.5%)

  

< 0.001

  1. AML = acute myeloid leukemia; ALL = acute lymphoblastic leukemia; ARDS = acute respiratory distress syndrome; CI = confidence interval; HSCT = hematopoietic stem cell transplantation; ICU = intensive care unit; NR = neutropenia recovery; RRT = renal replacement therapy.