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Table 4 Predictive value of the cuff leak test

From: Clinical review: Post-extubation laryngeal edema and extubation failure in critically ill adult patients

   Cuff leak cut off      
Author Year Volume (ml) Percentage of tidal volumea Outcome Sensitivity Specificity PPV NPV
Miller and Cole [27] 1996 110   PES 0.67 0.99 0.80 0.98
Jaber and colleagues[30] 2003 130 12 PES 0.85 0.95 0.69 0.98
de Bast and colleagues [36] 2002   15.5 Reintubation 0.75 0.72 0.25 0.96
Sandhu and colleagues [26] 2000   10.0 PES or reintubation 0.54 0.96 0.64 0.94
Wang and colleagues [14] 2007 88   PES    0.55 0.91
Maury and colleagues [25] 2004 0   PES 1.00 0.80 0.15 1.00
Chung and colleagues [55] 2006 140   Laryngeal edema 0.89 0.90 0.84 0.93
Engoren [56] 1999 110   PES 0.00 0.96 0.00 0.99
Kriner and colleagues [8] 2005 110   PES 0.50 0.84 0.12 0.97
Cheng and colleagues [3] 2006   18.0 PES 0.85 0.72 0.21 0.98
  1. NPV, negative predictive value; PPV, positive predictive value; PES, post-extubation stridor. aCuff leak volume as a percentage of inspiratory or expiratory tidal volume.