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Table 2 Resuscitation interventions utilized in the initial six hours

From: One year mortality of patients treated with an emergency department based early goal directed therapy protocol for severe sepsis and septic shock: a before and after study

Intervention

Before group

n = 79

After group

n = 206

P value*

Endotracheal intubation n, (%)

7 (9)

55 (27)

0.0006

Crystalloid volume (median, (IQR) liters)

2.0 (1.0-3.4)

5.0 (3.8-7.2)

< 0.0001

Vasopressor administration n, (%)

27 (34)

149 (72)

< 0.0001

Dobutamine administration n, (%)

1 (1)

9 (4)

0.22

PRBC transfusion n, (%)

1 (1)

13 (6)

0.07

Other

   

   Time to initial antibiotics (median, (IQR) minutes)

85 (50-190)

90 (55-156)

0.62

   Steroid administration n, (%)

5 (6)

88 (43)

< 0.0001

   Activated protein C n, (%)

3 (4)

5 (2)

0.54

ICU length of stay, days

2 ± 3

4 ± 5

< .0001

Total hospital days, days

8 ± 6

10 ± 9

.0670

  1. ICU = intensive care unit; IQR = interquartile range; PRBC = packed red blood cell.