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Table 2 Resuscitation interventions utilized in the initial six hours

From: One year mortality of patients treated with an emergency department based early goal directed therapy protocol for severe sepsis and septic shock: a before and after study

Intervention Before group
n = 79
After group
n = 206
P value*
Endotracheal intubation n, (%) 7 (9) 55 (27) 0.0006
Crystalloid volume (median, (IQR) liters) 2.0 (1.0-3.4) 5.0 (3.8-7.2) < 0.0001
Vasopressor administration n, (%) 27 (34) 149 (72) < 0.0001
Dobutamine administration n, (%) 1 (1) 9 (4) 0.22
PRBC transfusion n, (%) 1 (1) 13 (6) 0.07
Other    
   Time to initial antibiotics (median, (IQR) minutes) 85 (50-190) 90 (55-156) 0.62
   Steroid administration n, (%) 5 (6) 88 (43) < 0.0001
   Activated protein C n, (%) 3 (4) 5 (2) 0.54
ICU length of stay, days 2 ± 3 4 ± 5 < .0001
Total hospital days, days 8 ± 6 10 ± 9 .0670
  1. ICU = intensive care unit; IQR = interquartile range; PRBC = packed red blood cell.