Effects of positive end-expiratory pressure on respiratory function and hemodynamics in patients with acute respiratory failure with and without intra-abdominal hypertension: a pilot study

Krebs, Joerg; Pelosi, Paolo; Tsagogiorgas, Charalambos; Alb, Markus; Luecke, Thomas

doi:10.1186/cc8118

Critical Care

Table 3 Effect of PEEP on gas exchange and respiratory mechanics

From: Effects of positive end-expiratory pressure on respiratory function and hemodynamics in patients with acute respiratory failure with and without intra-abdominal hypertension: a pilot study

		PEEP 20	PEEP 15	PEEP 10	PEEP 5	P< 0.05 PEEP-level between groups:
PaO ₂ /FiO ₂	Normal IAP	238.67 ± 87.84^c	232.65 ± 85.17	191.33 ± 40.59	169.85 ± 44.09	NS
	IAH	218.72 ± 70.13^c	208.67 ± 67.54^e	181.25 ± 55.45	161.13 ± 47.59
PaCO ₂ , mmHg	Normal IAP	46.44 ± 8.20	46.40 ± 8.18	46.85 ± 8.12	46.88 ± 8.17	NS
	IAH	45.64 ± 8.44	47.00 ± 8.22	44.55 ± 7.43	45.27 ± 8.31
pH	Normal IAP	7.34 ± 0.1	7.34 ± 0.11	7.34 ± 0.10	7.34 ± 0.11	NS
	IAH	7.37 ± 0.06	7.38 ± 0.06	7.39 ± 0.04	7.39 ± 0.06
VT (ml/kg IBW)	Normal IAP	5.35 ± 0.43	5.36 ± 0.39	5.30 ± 0.43	5.31 ± 0.40	NS
	IAH	5.53 ± 0.30	5.58 ± 0.28	5.59 ± 0.32	5.59 ± 0.30
RR, breaths/min	Normal IAP	18.30 ± 3.20	18.30 ± 3.20	18.30 ± 3.20	18.30 ± 3.20	NS
	IAH	16.70 ± 3.20	16.70 ± 3.20	16.90 ± 3.21	16.90 ± 3.21
PEEP, cmH ₂ O	Normal IAP	20.00 ± 0.00	15.00 ± 0.00	10.00 ± 0.00	5.00 ± 0.00	20,15,10,5
	IAH	20.00 ± 0.00	15.00 ± 0.00	10.00 ± 0.00	5.00 ± 0.00
Pplat, cmH ₂ O	Normal IAP	36.30 ± 6.40^{a, b, c}	28.90 ± 3.21^{d, e}	23.50 ± 2.92^f	19.60 ± 3.66	NS
	IAH	35.80 ± 3,77^{a, b, c}	29.20 ± 3.16^{d, e}	24.50 ± 3.50^f	22.10 ± 4.70
Pes insp, cmH ₂ O	Normal IAP	22.70 ± 5.83^{a, b, c}	20.00 ± 3.94^{d, e}	17.80 ± 3.71^f	16.90 ± 4.36	NS
	IAH	24.69 ± 2.92^{a, b, c}	21.15 ± 3.42^e	19.25 ± 4.44^f	18.85 ± 6.48
Pes exp, cmH ₂ O	Normal IAP	16.40 ± 4.50^{a, b, c}	14.50 ± 3.63^{d, e}	12.50 ± 3.31^f	11.20 ± 3.52	NS
	IAH	16.91 ± 3.57^{a, b, c}	14.35 ± 2.58^{d, e}	12.55 ± 3.25^f	11.65 ± 3.53
Ptranspul insp, cmH ₂ O	Normal IAP	16.60 ± 9.65^{a, b, c}	11.90 ± 5.11^{d, e}	8.70 ± 3.33^f	5.70 ± 3.74	NS
	IAH	13.64 ± 3.75^{a, b, c}	11.05 ± 3.88^{d, e}	8.25 ± 4.97	6.25 ± 5.47
Ptranspul exp, cmH ₂ O	Normal IAP	6.60 ± 4.50^{a, b, c}	3.50 ± 3.63^{d, e}	0.50 ± 3.31^f	-3.20 ± 3.52	NS
	IAH	6.09 ± 3.57^{a, b, c}	3.65 ± 2.58^{d, e}	0.45 ± 3.25^f	-3.65 ± 3.53

FiO₂ = fraction of inspired oxygen; IAH = intra-abdominal hypertension; IAP = intra-abdominal pressure; IBW = ideal body weight; NS = not significant; PaCO₂ = partial pressure of arterial carbon dioxide; PEEP = positive end-expiratory pressure; Pes exp = expiratory esophageal pressure; PaO₂ = partial pressure of arterial oxygen; Pes insp = inspiratory esophageal pressure; Pplat = inspiratory plateau pressure; Ptranspulexp = expiratory transpulmonary pressure; Ptranspul insp = inspiratory transpulmonary pressure; RR = re spiratory rate; V_T = tidal volume.
^aP < 0.05 PEEP 20 vs. PEEP 15; ^bP < 0.05 PEEP 20 vs. PEEP 10; ^cP < 0.05 PEEP 20 vs. PEEP 5; ^dP < 0.05 PEEP 15 vs. PEEP 10; ^eP < 0.05 PEEP 15 vs. PEEP 5: ^fP < 0.05 PEEP 10 vs. PEEP 5.
Data are presented as mean ± standard deviation

Back to article page

ISSN: 1364-8535

Contact us

Submission enquiries: journalsubmissions@springernature.com