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Table 5 Significant predictors of overall treatment success, mycological response and mortality

From: Treatment of candidemia and invasive candidiasis in the intensive care unit: post hoc analysis of a randomized, controlled trial comparing micafungin and liposomal amphotericin B

Variable Ratio Without interaction termsa With interaction terms
    Maximum likelihood estimate (± standard error) Wald χ2 (probability > χ2)
Overall treatment success     
   ICU statusb Not in ICU to in ICU 1.866 (1.147 to 3.034) 0.1380 ± 0.5438 0.0644 (0.7997)
   Persistent neutropenia Non-neutropenic to neutropenic 5.721 (1.412 to 23.169) 1.7185 ± 0.7156 5.7669 (0.0163)
   APACHE II score High to low (continuous) 0.956 (0.929 to 0.983) --0.0468 ± 0.0144 10.6416 (0.011)
Mycological response     
   ICU statusb Not in ICU to in ICU 1.778 (1.037 to 3.048) --0.0223 ± 1.7567 0.0002 (0.9899)
   Primary diagnosis Candidemia to invasive candidiasis 2.465 (1.343 to 4.524) 0.3246 ± 0.4368 0.5522 (0.4574)
   Neutropeniab Non-neutropenic to neutropenic 2.357 (1.134 to 4.898) --0.9093 ± 1.0206 3.4859 (0.0619)
   Diabetes mellitus No to yes 0.350 (0.137 to 0.894) --1.0113 ± 0.5362 3.5572 (0.0593)
   APACHE II score High to low (continuous) 0.953 (0.925 to 0.982) --0.0505 ± 0.0154 10.7417 (0.001)
All-cause mortality at day 8     
   Candida spp. Candida krusei to other Candida spp. 3.536 (1.039 to 12.035) 2.4861 ± 1.3739 3.2745 (0.0704)
   APACHE II score High to low (continuous) 1.097 (1.055 to 1.142) 0.0931 ± 0.0208 20.0498 (< 0.0001)
All-cause mortality at day 30     
   Age Low to high 1.018 (1.003 to 1.033) 0.0170 ± 0.0076 4.9331 (0.0263)
   Persistent neutropenia Non-neutropenic to neutropenic 0.160 (0.039 to 0.658) --1.7845 ± 0.7146 6.2358 (0.0125)
   APACHE II score High to low (continuous) 1.093 (1.057 to 1.131) 0.0937 ± 0.0178 27.7797 (< 0.0001)
  1. Significant predictors of overall treatment success, mycological response and mortality based on a logistic regression model that controlled for potential confounding variables with and without interaction terms. APACHE, Acute Physiology and Chronic Health Evaluation; ICU, intensive care unit. aOdds ratio (95% confidence interval). bAt the time of treatment initiation.