Skip to main content

Table 5 Significant predictors of overall treatment success, mycological response and mortality

From: Treatment of candidemia and invasive candidiasis in the intensive care unit: post hoc analysis of a randomized, controlled trial comparing micafungin and liposomal amphotericin B

Variable

Ratio

Without interaction termsa

With interaction terms

   

Maximum likelihood estimate (± standard error)

Wald χ2 (probability > χ2)

Overall treatment success

    

   ICU statusb

Not in ICU to in ICU

1.866 (1.147 to 3.034)

0.1380 ± 0.5438

0.0644 (0.7997)

   Persistent neutropenia

Non-neutropenic to neutropenic

5.721 (1.412 to 23.169)

1.7185 ± 0.7156

5.7669 (0.0163)

   APACHE II score

High to low (continuous)

0.956 (0.929 to 0.983)

--0.0468 ± 0.0144

10.6416 (0.011)

Mycological response

    

   ICU statusb

Not in ICU to in ICU

1.778 (1.037 to 3.048)

--0.0223 ± 1.7567

0.0002 (0.9899)

   Primary diagnosis

Candidemia to invasive candidiasis

2.465 (1.343 to 4.524)

0.3246 ± 0.4368

0.5522 (0.4574)

   Neutropeniab

Non-neutropenic to neutropenic

2.357 (1.134 to 4.898)

--0.9093 ± 1.0206

3.4859 (0.0619)

   Diabetes mellitus

No to yes

0.350 (0.137 to 0.894)

--1.0113 ± 0.5362

3.5572 (0.0593)

   APACHE II score

High to low (continuous)

0.953 (0.925 to 0.982)

--0.0505 ± 0.0154

10.7417 (0.001)

All-cause mortality at day 8

    

   Candida spp.

Candida krusei to other Candida spp.

3.536 (1.039 to 12.035)

2.4861 ± 1.3739

3.2745 (0.0704)

   APACHE II score

High to low (continuous)

1.097 (1.055 to 1.142)

0.0931 ± 0.0208

20.0498 (< 0.0001)

All-cause mortality at day 30

    

   Age

Low to high

1.018 (1.003 to 1.033)

0.0170 ± 0.0076

4.9331 (0.0263)

   Persistent neutropenia

Non-neutropenic to neutropenic

0.160 (0.039 to 0.658)

--1.7845 ± 0.7146

6.2358 (0.0125)

   APACHE II score

High to low (continuous)

1.093 (1.057 to 1.131)

0.0937 ± 0.0178

27.7797 (< 0.0001)

  1. Significant predictors of overall treatment success, mycological response and mortality based on a logistic regression model that controlled for potential confounding variables with and without interaction terms. APACHE, Acute Physiology and Chronic Health Evaluation; ICU, intensive care unit. aOdds ratio (95% confidence interval). bAt the time of treatment initiation.