Matrix metalloproteinase-9, -10, and tissue inhibitor of matrix metalloproteinases-1 blood levels as biomarkers of severity and mortality in sepsis

Table 4 Correlation between MMP-9, MMP-10, and TIMP-1 serum levels with lactic acid, SOFA, platelets, and coagulation markers in sepsis patients

	Lactic acid (mmol/L)	APACHE-II (points)	SOFA (points)	Platelet count (platelets/mm³)	aPTT (seconds)	INR (ratio)
MMP-9: ng/ml	Rho = -0.31	Rho = -0.34	Rho = -0.37	Rho = 0.48	Rho = -0.28	Rho = -0.28
	P < 0.001	P < 0.001	P < 0.001	P < 0.001	P = 0.001	P = 0.001
TIMP-1: ng/ml	Rho = 0.51	Rho = 0.38	Rho = 0.42	Rho = -0.24	Rho = 0.29	Rho = 0.41
	P < 0.001	P < 0.001	P < 0.001	P = 0.001	P < 0.001	P < 0.001
MMP-10: pg/ml	Rho = 0.29	Rho = 0.33	Rho = 0.36	Rho = -0.24	Rho = 0.13	Rho = 0.22
	P < 0.001	P < 0.001	P < 0.001	P < 0.001	P = 0.13	P = 0.008
MMP-9/TIMP-1 ratio	Rho = -0.45	Rho = -0.42	Rho = -0.48	Rho = 0.49	Rho = -0.38	Rho = -0.4
	P < 0.001	P < 0.001	P < 0.001	P < 0.001	P < 0.001	P < 0.001
MMP-10/TIMP-1 ratio	Rho = 0.01	Rho = 0.11	Rho = 0.04	Rho = -0.08	Rho = -0.09	Rho = -0.03
	P = 0.95	P = 0.13	P = 0.77	P = 0.30	P = 0.29	P = 0.72

aPTT = Activated partial thromboplastin time; INR = international normalized ratio; MMP = matrix metalloproteinase; rho = Spearman's rank correlation coefficient; SOFA = Sepsis-related Organ-Failure Assessment score; TIMP = tissue inhibitor of matrix metalloproteinase.

ISSN: 1364-8535