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Table 2 Demographic and clinical parameters of surviving and nonsurviving sepsis patients (median and 25 th to 75 th percentiles or percentage when indicated are shown)

From: Matrix metalloproteinase-9, -10, and tissue inhibitor of matrix metalloproteinases-1 blood levels as biomarkers of severity and mortality in sepsis

 

Survivors

(n = 125)

Nonsurvivors

(n = 67)

P

Gender female: number (%)

40 (31.2)

24 (37.5)

0.27

Age: median years (percentile 25-75)

56 (47-69)

62 (52-71)

0.15

Diabetes mellitas: number (%)

25 (19.8)

24 (37.5)

0.02

COPD: number (%)

17 (13.5)

10 (15.6)

0.67

Site of infection

  

0.82

   • Respiratory: number (%)

67 (53.2)

38 (59.4)

 

   • Abdominal: number (%)

28 (22.2)

13 (20.3)

 

   • Other sites: number (%)

31(24.6)

13 (20.3)

 

APACHE-II score: median (percentile 25-75)

19 (14-22)

24 (18-29)

<0.001

Creatinine (mg/dl): median (percentile 25-75)

1.2 (0.80-2.05)

1.6 (0.9-2.8)

0.02

Leukocytes: median/mm3 (percentile 25-75)

14,600 (8,900-20,050)

15,200 (9,050-20,625)

0.39

Lactic acid: median mmol/L (percentile 25-75)

2,00 (1.20-3.70)

3.95 (1.47-6.55)

<0.001

Platelets: median/mm3 (percentile 25-75)

210,000 (127,000-273,000)

139,000 (63,000-218,250)

<0.001

INR: median (percentile 25-75)

1.27 (1.10-1.50)

1.42 (1.10-1.66)

0.17

aPTT: median seconds (percentile 25-75)

30 (26-39)

39 (30-47)

<0.001

SOFA store: median (percentile 25-75)

9 (7-11)

12 (9-14)

<0.001

   • Respiratory: median (percentile 25-75)

3 (2-3)

3 (2-3)

0.07

   • Hematologic: median (percentile 25-75)

0 (0-1)

1 (0-2)

<0.001

   • Hepatic: median (percentile 25-75)

0 (0-1)

0 (0-1)

0.75

   • Cardiovascular: median (percentile 25-75)

4 (4-4)

4 (4-4)

0.006

   • Neurologic: median (percentile 25-75)

0 (0-1)

0 (0-3)

0.22

   • Renal: median (percentile 25-75)

0 (0-2)

2 (0-4)

<0.001

  1. APACHE II = Acute Physiology and Chronic Health Evaluation; aPTT = activated partial thromboplastin time; COPD = chronic obstructive pulmonary disease; INR = international normalized ratio; SOFA = Sepsis-related Organ-failure Assessment score.