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Table 1 Patient characteristics by cohort

From: Candidemia on presentation to the hospital: development and validation of a risk score

 

Number of admissions (% of total)

 

Characteristic

Derivation cohort (n = 64,019)

Validation cohort (n = 24,685)

P value

Candidemia

738 (1.2)

321 (1.3)

0.0697

Demographics

   

   Age < 65 years

19,523 (30.5)

8403 (34.0)

< 0.0001

   Men

29,845 (46.6)

12,090 (49.0)

< 0.0001

   Mortality

9664 (15.1)

3173 (12.9)

< 0.0001

Laboratory findings

   

   Albumin ≤ 1.8 g/dL

2704 (4.2)

1278 (5.2)

< 0.0001

   Albumin 1.9--2.2 g/dL

3800 (5.9)

1757 (7.1)

< 0.0001

   Arterial pH ≤ 7.36

5913 (9.2)

2684 (10.9)

< 0.0001

   Potassium > 5.6 mEq/dL

3133 (4.9)

1182 (4.8)

0.5150

   Sodium > 145 mEq/dL

3600 (5.6)

1206 (4.9)

< 0.0001

   Bands > 32%

5345 (8.4)

1813 (7.4)

< 0.0001

   White blood cells > 27,000/mm3

5096 (8.0)

1980 (8.0)

0.7604

Vital signs and mental status

   

   Temperature ≤ 98°F

16,917 (26.4)

4780 (19.4)

< 0.0001

   Severe altered mental statusa

6301 (9.8)

2255 (9.1)

0.0014

   Temperature ≤ 98°F or severe altered mental status

21,140 (33.0)

6454 (26.1)

< 0.0001

History and severe comorbidities

   

   Metastatic cancer

3245 (5.1)

1262 (5.1)

0.7910

   Tumor

2693 (4.2)

1136 (4.6)

0.0094

   Cachexiab

4549 (7.1)

2392 (9.7)

< 0.0001

Other variables

   

   Prior-admission within 30 days

11,215 (17.5)

4603 (18.7)

< 0.0001

   Admitted from other healthcare facility

12,813 (20.0)

5581 (22.6)

< 0.0001

   Mechanical ventilation at admission

5864 (9.2)

2695 (10.9)

< 0.0001

  1. aSevere altered mental status defined as Glasgow Coma Scale less than 5 or a designation of coma by a physician.
  2. bCachexia defined by ICD-9 secondary diagnosis code.
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