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Table 2 RH-PAT index and related variables at time of initial measurement

From: Sepsis-associated microvascular dysfunction measured by peripheral arterial tonometry: an observational study

 

Severe sepsis

Sepsis without organ failure

Control

P value pooled sepsis v control

P value severe sepsis vs SWOF

N

54

31

45

  

RH-PAT index a

1.57 (1.43-1.70)

1.85 (1.67-2.03)

2.05 (1.91-2.19)

< 0.00001

0.01

Plasma L-arginine (μmol/L)

35.8 (30.2-41.4)

40.9 (33.5-48.3)

80.4 (72.3-88.6)

< 0.00001

NS

MAP (mmHg) a

77 (74-81)

89 (83-95)

83 (79-87)

NS

0.0006

Receiving vasopressors n (%)

27 (50)

0

   

Noradrenaline dose (μg/kg/min) b, c

0.08 (0.03-0.42)

    

Receiving assisted ventilation n (%)

20 (37)

0

   

CVP (cmH20) a

12.2 (10.3-14.1)

    

Plasma ICAM-1 (ng/ml) b

811 (500-1502)

507 (368-673)

323 (252-397)

< 0.00001

0.003

Plasma E-selectin (ng/ml) b

329 (138-502)

90 (51-164)

38 (26-63)

< 0.00001

0.0003

Plasma IL 6 (pg/ml) b

385 (124-996)

148 (46-315)

5 (2-8)

< 0.00001

0.009

White blood cell count a

16.7 (14.2-19.2)

15.5 (13.3-17.7)

8.4 (6.9-9.8)

< 0.00001

NS

C-reactive protein b

190 (131-255)

102 (84-234)

7 (3-24)

< 0.00001

NS

  1. a. mean (95% confidence interval)
  2. b. Median (interquartile range)
  3. c. Of 27 patients receiving vasopressors, 25 were receiving noradrenaline
  4. d. Severe sepsis n = 30, sepsis without organ failure n = 26, control n = 2.
  5. CVP = central venous pressure; ICAM = intra-cellular adhesion molecule-1; NS = not significant; MAP = mean arterial pressure; RH-PAT = reactive hyperaemia peripheral arterial tonometry; SWOF = sepsis without organ failure.