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Table 2 RH-PAT index and related variables at time of initial measurement

From: Sepsis-associated microvascular dysfunction measured by peripheral arterial tonometry: an observational study

  Severe sepsis Sepsis without organ failure Control P value pooled sepsis v control P value severe sepsis vs SWOF
N 54 31 45   
RH-PAT index a 1.57 (1.43-1.70) 1.85 (1.67-2.03) 2.05 (1.91-2.19) < 0.00001 0.01
Plasma L-arginine (μmol/L) 35.8 (30.2-41.4) 40.9 (33.5-48.3) 80.4 (72.3-88.6) < 0.00001 NS
MAP (mmHg) a 77 (74-81) 89 (83-95) 83 (79-87) NS 0.0006
Receiving vasopressors n (%) 27 (50) 0    
Noradrenaline dose (μg/kg/min) b, c 0.08 (0.03-0.42)     
Receiving assisted ventilation n (%) 20 (37) 0    
CVP (cmH20) a 12.2 (10.3-14.1)     
Plasma ICAM-1 (ng/ml) b 811 (500-1502) 507 (368-673) 323 (252-397) < 0.00001 0.003
Plasma E-selectin (ng/ml) b 329 (138-502) 90 (51-164) 38 (26-63) < 0.00001 0.0003
Plasma IL 6 (pg/ml) b 385 (124-996) 148 (46-315) 5 (2-8) < 0.00001 0.009
White blood cell count a 16.7 (14.2-19.2) 15.5 (13.3-17.7) 8.4 (6.9-9.8) < 0.00001 NS
C-reactive protein b 190 (131-255) 102 (84-234) 7 (3-24) < 0.00001 NS
  1. a. mean (95% confidence interval)
  2. b. Median (interquartile range)
  3. c. Of 27 patients receiving vasopressors, 25 were receiving noradrenaline
  4. d. Severe sepsis n = 30, sepsis without organ failure n = 26, control n = 2.
  5. CVP = central venous pressure; ICAM = intra-cellular adhesion molecule-1; NS = not significant; MAP = mean arterial pressure; RH-PAT = reactive hyperaemia peripheral arterial tonometry; SWOF = sepsis without organ failure.