Table 1
From: Fungaemia in the intensive care unit: Baragwanath experience
Demographics: | Â | Â | Â | Â | Â |
|---|---|---|---|---|---|
| Â | Â | Total (n=26) | Alive (n=8) | Dead (n=18) | P |
Age (years) | Median (range) | 47 (8d-76y) | 26 (10m-53y) | 48.5 (8d-76y) | 0.182 |
APACHE II (n=20) | Mean (SD) | 16.9 (7.4) | 11.6 (6.1) | 18.6 (7.0) | 0.06 |
PRISM (n=6) | Mean (SD) | 12.7 (5.8) | 8.6 (5.0) | 16.6 (3.1) | 0.07 |
ICU stay (days) | Median (range) | 13.5 (1-115) | 15.5 (3-71) | 11 (1-115) | 0.88 |
Delay to Rx (days) | Mean (SD) | 2.6 (3.6) | 8.0 (1.5) | 1.2d (2.6) | <0.05 |
Microbiology: | Â | Â | Â | Â | Â |
Mean time to initial fungaemia following ICU admission was 6.5 days (25th-75th: 2-14). The mean time of isolation of fungi from tracheal aspirate | |||||
(n=9), catheter tip (n=7), urine (n=6) was 4.4 (SD 4.4), 12.3 (SD 13) and 21.8 (SD 18.2) days respectively. | |||||
Response to therapy at 2 weeks: | Â | Â | Â | Â | Â |
| Â | N | Cured | Relapse | Died during therapy | Â |
Albicans | 10 | 3 | 0 | 7 | 70% |
Glabrata | 5 | 0 | 2 | 3 | 60% |
Parapsilosis | 10 | 6 | 0 | 4 | 40% |
Glabrata+Parapsilosis | 1 | 0 | 0 | 1 | 100% |
≤ 5 risk factors | 11 | 6 | 0 | 5 | 45% |
≥ 6 | 15 | 3 | 2 | 10 | 66% |