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Inhibition of cytokine release by VX-166 (n = 4 per assay).
VX-166: a novel potent small molecule caspase inhibitor as a potential therapy for sepsis
IC50 ± SD (nM)
IL-1β/LPS-treated human PBMC
260 ± 120
IL-18/SAC-treated human PBMC
450 ± 170
= 50% inhibitory concentration; LPS = lipopolysaccharide; PBMC = peripheral blood mononuclear cells; SAC =
cell suspension; SD = standard deviation.
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