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Table 2 Inhibition of apoptosis by VX-166 in a variety of cell-based assays (n = 4 per assay).

From: VX-166: a novel potent small molecule caspase inhibitor as a potential therapy for sepsis

Apoptotic stimulus Cell type/readout IC50 (nM)
Anti-Fas Human Jurkat cell line/Annexin V 27 ± 9
Anti-Fas Human Jurkat cell line/DNA fragmentation 45 ± 7
TNF-α/cycloheximide Human Jurkat cell line/Annexin V 120 ± 50
Staurosporine Human Jurkat cell line/Annexin V 255 ± 155
Serum withdrawal and nutrient deprivation HAEC/DNA fragmentation 310 ± 70
  1. IC50 = 50% inhibitory concentration; HAEC = human aorta endothelial cells.