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Table 2 Inhibition of apoptosis by VX-166 in a variety of cell-based assays (n = 4 per assay).

From: VX-166: a novel potent small molecule caspase inhibitor as a potential therapy for sepsis

Apoptotic stimulus

Cell type/readout

IC50 (nM)

Anti-Fas

Human Jurkat cell line/Annexin V

27 ± 9

Anti-Fas

Human Jurkat cell line/DNA fragmentation

45 ± 7

TNF-α/cycloheximide

Human Jurkat cell line/Annexin V

120 ± 50

Staurosporine

Human Jurkat cell line/Annexin V

255 ± 155

Serum withdrawal and nutrient deprivation

HAEC/DNA fragmentation

310 ± 70

  1. IC50 = 50% inhibitory concentration; HAEC = human aorta endothelial cells.
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Critical Care

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