Figure 4
From: VX-166: a novel potent small molecule caspase inhibitor as a potential therapy for sepsis
VX-166 improves survival following CLP in the rat when dosed post insult. The compound was administered by mini-osmotic pump (10 μl/h for seven days, 25 mg/ml) implanted subcutaneously at different times after caecal ligation and puncture (CLP) and survival was monitored over 10 days (n = 12 per group). (a) VX-166 dosed at 0 hours (empty squares) vs. vehicle control (filled squares); *P = 0.026 (b) VX-166 dosed at three hours (empty triangles) vs. vehicle control (filled triangles); *P = 0.009. (c) VX-166 dosed at eight hours (empty circles) vs. vehicle control (filled circles).