Figure 3
From: VX-166: a novel potent small molecule caspase inhibitor as a potential therapy for sepsis
VX-166 significantly improves survival following CLP in the rat. (a) Dose response of VX-166. The compound was administered by mini-osmotic pump (10 μl/h for seven days) implanted subcutaneously immediately after caecal ligation and puncture (CLP) and survival was monitored over seven days(n = 12 per group). VX-166 was dosed at 5 (diamonds), 15 (triangles), or 25 mg/ml (squares) vs. vehicle control (circles); *P < 0.05 logrank test for trend. (b) Single dose study using the optimal dose (25 mg/ml) of VX-166 (squares) vs. vehicle control (circles). The compound was administered by mini-osmotic pump (10 μl/h for seven days) implanted subcutaneously immediately after CLP and survival was monitored over 10 days (n = 16 per group); *P < 0.01.