Table 2 Randomized controlled trials of ventilator weaning strategies
From: The paradox of ventilator-associated pneumonia prevention measures
| Impact on | ||||||
|---|---|---|---|---|---|---|
| Subjects | VAP rates | Ventilator LOS | ICU LOS | Hospital LOS | Mortality | |
| Daily spontaneous breathing trial | ||||||
| Esteban, et al., 1995 [35] | 546 | - |
40% ↓ (-2 days) | - | - | - |
| Ely, et al., 1996 [34] | 300 | - |
25% ↓ (-1.5 days) | NS | NS | NS |
| Kollef, et al., 1997 [33] | 357 | - |
20% ↓ (-0.4 days) | - | NS | NS |
| Marelich, et al., 2000 [32] | 385 | NS |
45% ↓ (-2.3 days) | - | - | NS |
| Lellouche, et al., 2006 [36] | 144 | NS |
38% ↓ (-4.5 days) |
22.6% ↓ (-3.5 days) | NS | NS |
| Daily sedative interruption | ||||||
| Kress, et al., 2000 [37] and | 128 | NS |
33% ↓ (-2.4 days) |
35% ↓ (-3.5 days) | NS | NS |
| Schweickert, et al., 2004 [65] | ||||||
| Daily spontaneous breathing trial and sedative interruption | ||||||
| Girard, et al., 2008 [38] | 336 | - |
19% ↓ (-3.1 days) |
29% ↓ (-3.8 days) |
22% ↓ (-4.3 days) |
28 days: NS 1 year: 32% ↓ |