Table 2 Randomized controlled trials of ventilator weaning strategies
From: The paradox of ventilator-associated pneumonia prevention measures
Impact on | ||||||
|---|---|---|---|---|---|---|
Subjects | VAP rates | Ventilator LOS | ICU LOS | Hospital LOS | Mortality | |
Daily spontaneous breathing trial | ||||||
Esteban, et al., 1995 [35] | 546 | - | 40% ↓ (-2 days) | - | - | - |
Ely, et al., 1996 [34] | 300 | - | 25% ↓ (-1.5 days) | NS | NS | NS |
Kollef, et al., 1997 [33] | 357 | - | 20% ↓ (-0.4 days) | - | NS | NS |
Marelich, et al., 2000 [32] | 385 | NS | 45% ↓ (-2.3 days) | - | - | NS |
Lellouche, et al., 2006 [36] | 144 | NS | 38% ↓ (-4.5 days) | 22.6% ↓ (-3.5 days) | NS | NS |
Daily sedative interruption | ||||||
Kress, et al., 2000 [37] and | 128 | NS | 33% ↓ (-2.4 days) | 35% ↓ (-3.5 days) | NS | NS |
Schweickert, et al., 2004 [65] | ||||||
Daily spontaneous breathing trial and sedative interruption | ||||||
Girard, et al., 2008 [38] | 336 | - | 19% ↓ (-3.1 days) | 29% ↓ (-3.8 days) | 22% ↓ (-4.3 days) | 28 days: NS 1 year: 32% ↓ |