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Table 2 Randomized controlled trials of ventilator weaning strategies

From: The paradox of ventilator-associated pneumonia prevention measures

  Impact on
  Subjects VAP rates Ventilator LOS ICU LOS Hospital LOS Mortality
Daily spontaneous breathing trial       
   Esteban, et al., 1995 [35] 546 - 40% ↓
(-2 days)
- - -
   Ely, et al., 1996 [34] 300 - 25% ↓
(-1.5 days)
NS NS NS
   Kollef, et al., 1997 [33] 357 - 20% ↓
(-0.4 days)
- NS NS
   Marelich, et al., 2000 [32] 385 NS 45% ↓
(-2.3 days)
- - NS
   Lellouche, et al., 2006 [36] 144 NS 38% ↓
(-4.5 days)
22.6% ↓
(-3.5 days)
NS NS
Daily sedative interruption       
   Kress, et al., 2000 [37] and 128 NS 33% ↓
(-2.4 days)
35% ↓
(-3.5 days)
NS NS
   Schweickert, et al., 2004 [65]       
Daily spontaneous breathing trial and sedative interruption       
   Girard, et al., 2008 [38] 336 - 19% ↓
(-3.1 days)
29% ↓
(-3.8 days)
22% ↓
(-4.3 days)
28 days: NS
1 year: 32% ↓
  1. ICU, intensive care unit; LOS, length of stay; NS, no statistically significant impact; VAP, ventilator-associated pneumonia; Ventilator LOS, duration of mechanical ventilation.